Untitled - D Ank Unlimited

adiomimetic drug 610 Raji cell assay
radiomimetic drug
An immunosuppressive drug such as an alkylating agent
used in the treatment of cancer. Its effect on DNA mimics
that of ionizing radiation.
RAG-1 and RAG-2
Refer to recombination-activating genes 1 and 2.
RAG blastocyst complementation
A method employed to test gene function when its null mutation
in the body is embryonic lethal. RAG mice are bereft
of both T and B cells. The introduction of embryonic stem
cells from a particular mutant whose RAG genes are intact
into the eight-cell stage blastocyst of a RAG -/- developing
embryo results in absorption of new cells by the embryo,
which proceeds with normal development following implantation.
Different regions of chimeric embryos are the sources
of different tissues, leading to viable reconstituted mice that
possess lymphoid systems expressing the specific mutation.
This technique permits determination of the effect of the
mutation on lymphocyte development and function.
RAG recombinases
Recombination activation gene recombinases. RAG-1 and
RAG-2 are the main enzymes that facilitate V(D)J gene
segment recombination in immunoglobulin and T cell
receptor loci. Only developing B and T cells express the
RAG genes.
Ragg
Agglutinating activity by rheumatoid factor in the sera of
patients with rheumatoid arthritis, as revealed by a positive
rheumatoid arthritis (RA) test.
Ambrosia artemisiaefolia, commonly termed ragweed.
Raji cell
with receptors
for complement
Ag
Ab
Complement
ragocyte
Polymorphonuclear leukocytes containing IgG–rheumatoid
factor–complement–fibrin conglomerates found in the joints
of patients with rheumatoid arthritis. Also called RA cells.
ragweed
Ragweed (genus Ambrosia) is distributed throughout the
warmer parts of the Western Hemisphere but poses the
greatest clinical problem in North America. Airborne
ragweed pollen constitutes a troublesome respiratory allergen.
It appears in the air in the northern United States and
adjacent eastern Canada in late July and reaches levels up
to thousands of grains per cubic meter by early September,
after which the level declines. Pure ragweed pollinosis
has usually subsided by mid-October in the north. Short
ragweed (A. artemisiaefolia) and giant ragweed (A. trifida)
range widely from the Atlantic coast to the Midwest, Ozark
plateau, and Gulf states. Short ragweed reaches to northern
Mexico and is found only sparsely in the Pacific Northwest.
Giant ragweed is abundant in the Mississippi Delta and
along the flood plains of southeastern rivers. The following
ragweed pollen allergens have been characterized:
Allergen Source Allergen
Ambrosia
artemisiaefolia
(ragweed)
Ambrosia trifida
(giant ragweed)
Molecular Weight
(kDa) SDS–PAGe
AMB α I (AGE) 38
AMB α II (AGK) 38
AMB α III (Ia3) 12
AMB α IV (Ra4) 23
AMB α V (Ra5) 5
AMB α VI (Ra6) 8
AMB α VII —
AMB T V (Ra6) 4.4
Raji cell assay
An in vitro assay for immune complexes in serum. The
technique employs Raji cells, a lymphoblastoid B lymphocyte
tumor cell line that expresses receptors for complement
receptor 1, complement receptor 2, FCγ, and C1q receptors.
The cell line does not express surface immunoglobulins.
Radiolabeled antihuman Ig
Raji cell assay.