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pyroglobulins 604 pyroninophilic cells
pyroglobulins
Monoclonal immunoglobulins that undergo irreversible precipitation
upon heating to 56°C. They are usually detected
during routine inactivation of complement in serum by
heating to 56°C in a water bath. Whereas most immunoglobulins
are unharmed at this temperature, pyroglobulins
precipitate. This may be attributable to formation of
hydrophobic bonds linking immunoglobulin molecules as
a consequence of diminished heavy chain polarity. Half of
the pyroglobulin-positive subjects have multiple myeloma,
and the remaining half have lymphoproliferative disorders
such as macroglobulinemia, carcinoma, or systemic lupus
erythematosus. The relevance of pyroglobulins to disease is
unknown.
pyroninophilic cells
Cells whose cytoplasm stains red with methyl green
pyronin stain. This signifies large quantities of RNA in
the cytoplasm, indicating active protein synthesis. For
example, plasma cells and other protein-producing cells are
pyroninophilic.