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pseudoallergy 601 psoriasis vulgaris
P selection (NMR).
pseudoallergy
An anaphylaxis-like reaction that occurs suddenly, frequently
following food ingestion, and represents an anaphylactoid
reaction. It may be induced by a psychogenic factor, a metabolic
defect, or other nonimmunological cause. This is not an
immune reaction and is classified as an anaphylactoid reaction.
pseudogene
A sequence of DNA that is similar to a sequence of a true
gene but does not encode a protein due to defects that
inhibit gene expression. Pseudogenes represent nonusable or
junk DNA. They may result from duplicated genes and have
several defects as mutations accumulate.
pseudolymphoma
Hyperplasia of lymphoid tissue involving a uniform accumulation
of lymphocytes. Unlike lymphomas, the cells are polyclonal.
The architecture of the lymph nodes is well preserved,
with distinct cortical germinal centers showing little or minimal
capsular infiltration by lymphocytes. Inflammatory cells
are detectable between germinal centers, but mitoses occur
only within the centers. The reticular framework remains
intact. The lymphoid hyperplasia that characterizes pseudolymphoma
may be found in various locations such as gastrointestinal
tract, lung, breast, salivary gland, mediastinum, skin,
Stratum
corneum
Basement
membrane Dermal
vessels
Chondro-fibrous
junction
Marginal cartilage
Fluorescent
deposits
Psoriasis vulgaris.
soft tissue, and other areas. Pseudolymphomas may occur in
individuals who later develop lymphomas.
pseudolymphomatous lymphadenitis
Hyperplasia of lymphoid organs that is similar to lymphoma
except that the hyperplasia is reversible.
Pseudomonas aeruginosa immunity
Pseudomonas aeruginosa infection is followed by the
development of antibodies that facilitate opsonophagocytosis
and protection against subsequent infections. An
adequate antibody response is required for protection.
Antibody alone may be insufficient because the lungs of
patients with cystic fibrosis continue to be chronically
colonized even in the presence of potent serum antibody
responses to several antigens of this microorganism.
Active vaccination is made less desirable by the fact that
P. aeruginosa infections cannot be reliably predicted;
thus, passively administered hyperimmune intravenous
immunoglobulin from immunized volunteers has been
used to confer protection. Nevertheless, contemporary
investigations show that antibodies against lipopolysaccharide
(LPS) serotypes and to exotoxin A do not significantly
protect recipients.
pseudoparaproteinemia
An elevation of transferrin to levels at least twice normal
(200 to 400 mg/dL). Profound iron deficiency anemia leads
to this increase. The one molecular form of transferrin in
the serum is concentrated into a single band that travels in
the β region in serum electrophoresis, giving the appearance
of a paraproteinemia. However, a real paraproteinemia
is characterized by a spike on serum electrophoresis representing
a monoclonal gammopathy.
pseudopodia
Membrane extensions from motile and phagocytic cells.
psoriasis vulgaris
A chronic, recurrent, papulosquamous autoimmune disease
attributed to improper functioning of keratinocytes. Marked
P