Untitled - D Ank Unlimited

proteasome genes 598 protein P
proteasome genes
Two genes in the major histocompatibility complex
(MHC) class II region that encode two proteasome subunits.
The proteasome is a protease complex in the cytosol
that may participate in the generation of peptides from
proteins in the cytosol.
N-CHO NH 2
GPI
CD59
C5b-8
C5b-8
protectin (CD59)
A protein on cell surfaces that guards host cells from
complement-mediated injury. It prevents the formation of
the membrane attack complex by inhibiting C8 and C9
binding to the C5b–6–7 complex.
protective antigens
The antigenic determinants of a pathogenic microorganism
that stimulate an immune response that can protect a host
against an infection by the microorganism. These specific
antigenic specificities can be used for prophylactic immunization
in vaccines to immunize susceptible hosts against
possible future infections.
protective epitopes
Antigenic determinants of a pathogenic microorganism that
stimulate a protective immune response against the same
microorganism. Refer to protective antigens.
protective immunity
Natural, nonspecific immune mechanisms and actively
acquired specific immunity that result in the defense of
a host against a particular pathogenic microorganism.
Protective immunity may be induced by active immunization
with a vaccine prepared from antigens of a pathogenic
microorganism or by experiencing a subclinical or clinical
infection from the microorganism.
protein A
A Staphylococcus aureus bacterial cell wall protein
composed of a solitary polypeptide chain whose binding
sites manifest affinity for the Fc region of immunoglobulin
G (IgG). It combines with IgG 1, IgG 2, and IgG 4 but
not IgG 3 subclasses in humans; with the IgG subclasses
of mice; and with the IgG of rabbits and certain other
species. It has been used extensively for the isolation of
IgG during protein purification and for the protection of
IgG in immune (antigen–antibody) complexes. Protein
A is antiphagocytic, a property that may be linked to its
ability to bind the Fc region of an opsonizing antibody.
Protein A has been postulated to facilitate escape from the
immune response by masking its epitopes with immunoglobulins.
It is used for mitogenic stimulation of human
B lymphocytes, investigation of lymphocyte Fc receptors,
agglutination tests, and the detection and purification of
immunoglobulins by the enzyme-linked immunosorbent
assay (ELISA) technique.
C9
Protectin (CD59).
CD59
C5b-8
C9
CD
protein AA
An 8.5-kDa protein isolated by gel filtration and comprised
of 76 amino acids. The sequence has no relationship to those
of immunoglobulins or other known sequences of human
proteins. The sequence of protein AA extracted from various
tissues appears identical, but several genetic variants are
identified by sequence analysis. The molecule lacks cysteine
and accordingly has no cross links. The N terminal residue
is arginine (in humans), and in some the second amino acid
is phenylalanine. AA also lacks carbohydrate and other
attached small molecules. Amyloid protein AA is insoluble
in ordinary aqueous solvents. Protein AA is the predominant
component in the secondary form of amyloidosis.
protein B
A group B streptococcal protein capable of binding the Fc
regions of immunoglobulin A (IgA) molecules. It is used in
immunoassays and purification techniques for human serum
and secretory IgA. It has the unique capacity to bind specifically
to human IgA 1 and IgA 2 subclasses and shows no cross
reactivity with other immunoglobulin classes or serum proteins.
protein blotting
Refer to immunoblotting.
protein F
Fusion protein; a 70-kDa glycoprotein believed critical to
the generation of an effective immune response against
respiratory syncytial virus.
protein G
An antibody-binding protein that combines securely and
specifically with certain species of antibody. (1) A group G
streptococcus cell wall constituent that combines with IgG
Fc regions of four IgG subclasses that may be significant in
host resistance to this microorganism. (2) A 90-kDa attachment
glycoprotein that is critical in the immune response
to respiratory syncytial virus (RSV). G protein antigenic
differences are associated with RSV strain differences.
NH 2
Regulatory domain
ATP binding
Proteolytic cleavage
Variable region
Constant region
Protein kinase C.
Catalytic domain
COOH
protein kinase C (PKC)
A serine/threonine kinase that Ca 2+ activates in the cytoplasm
of cells. It participates in T and B cell activation and
is a receptor for phorbol ester that acts by signal transduction,
leading to hormone secretion, enzyme secretion,
neurotransmitter release, and mediation of inflammation.
It is also involved in lipogenesis and gluconeogenesis and
participates in differentiation of cells and tumor promotion.
protein M (M antigen)
Group A streptococcal protein found on fimbriae. It is
antiphagocytic and facilitates virulence of streptococci.
protein P
A 23-kDa pentameric protein detectable in amyloid deposits.