Untitled - D Ank Unlimited

Pressman, David 591 primary biliary cirrhosis (PBC)
the cytosol for conveyance to TAP. Peptides are united
to gp96 or PDI in the endoplasmic reticulum on the other
side of TAP.
Pro-T
Pre-T
Cytoplasmic CD3 Cytoplasmic CD3
Cytotoxic
T cell
Surface CD3
Pre-T cell development.
David Pressman.
Helper
T cell
Pressman, David
Colleague of Linus Pauling and an immunochemist who
completed important work at the Roswell Park Memorial
Institute in Buffalo, New York.
pre-T chain (pT )
Invariant transmembrane T cell receptor α-like chain
manifested exclusively by double negative thymocytes.
Employed for productivity assays of candidate TCRβ
chains. Not requisite for γδ T cell development. Refer to
pre-T cell receptor.
pre-T cell
A stage in the maturation of T lymphocytes in the thymus
in which cells express the T cell receptor (TCR) β chain, but
not the α chain or the CD4 or CD8 markers. The pre-T cell
expresses the TCR β polypeptide chain on the cell surface
together with the pTa (gp33) molecule to form the pre-T cell
receptor.
pre-T cell receptor (pre-TCR)
A receptor on the surfaces of pre-T cells composed of the
TCR β chain and the invariant pre-T α chain. This receptor
associates with CD3 and ζ molecules to form the pre-T cell
receptor complex. It functions similarly to pre-B cell receptors
and B cell development in that it delivers signals that stimulate
further proliferation, antigen receptor gene rearrangements,
and other events related to maturation. It is unknown whether
the pre-T cell receptor binds a specific antigen.
pre-TCR activation
Throughout β selection, the swift proliferation of only
thymocyte clones that possess functional TCR β chains.
Triggered by pTα signaling induced by an unidentified
ligand.
pre-T lymphocyte
Refer to prothymocyte.
prevertebrates
Animals without backbones that evolved from a deuterstome
ancestor. Echinoderms (starfish, sea urchins) and protochordates
(ascidians and tunicates, including sea squirts)
are examples.
1. Antigens 1–4
dropped on
to skin
Control
(Several minutes later)
Wheal and flare
reaction to antigen 3
2. Skin is lightly pricked
Prick test.
prick test
An assay for immediate (IgE-mediated) hypersensitivity
in humans. The epidermal surface of the skin on which
drops of diluted antigen (allergen) are placed is pricked by a
sterile needle passed through an allergen. The reaction produced
is compared with one induced by histamine or another
mast cell secretogogue. This test is convenient, simple, and
rapid and produces little discomfort in comparison with the
intradermal test. It even may be used for infants.
primary agammaglobulinemia
Refer to antibody deficiency syndrome.
primary allergen
The antigenic material that sensitizes a patient who subsequently
shows cross sensitivity to a related allergen.
primary biliary cirrhosis (PBC)
A chronic liver disease of unknown cause that affects
middle-aged women in 90% of the cases. It involves chronic
intrahepatic cholestasis caused by chronic inflammation
and necrosis of intrahepatic bile ducts with progression to
biliary cirrhosis. It is believed to be autoimmune based on its
association with autoimmune conditions and the presence of
autoantibodies. Patients develop pruritis, fatigue, steatorrhea,
renal tubular acidosis, hepatic osteodystrophy, and increased
incidence of hepatocellular carcinoma and breast carcinoma.
Four fifths of patients also have a connective tissue or
autoimmune diseases such as rheumatoid arthritis, autoimmune
thyroiditis, scleroderma, and Sjögren’s syndrome. Most
P