Untitled - D Ank Unlimited

phagolysosome 571 phorbol ester(s)
O
CH 3 CH 2 CH 2 CH 2
function, neutropenia, or abnormal neutrophil chemotaxis.
Intrinsic phagocytic dysfunction is related to deficiencies in
enzymatic killing of engulfed microorganisms. Examples of
the intrinsic disorders include chronic granulomatous disease,
myeloperoxidase deficiency, and glucose-6-phosphate
dehydrogenase deficiency. Consequences of phagocytic
dysfunction include increased susceptibility to bacterial
infections but not to viral or protozoal infections. Selected
phagocytic function disorders may be associated with severe
fungal infections. Severe bacterial infections associated with
phagocytic dysfunction range from mild skin infections to
fatal systemic infections.
phagolysosome
A cytoplasmic vesicle with a limiting membrane produced
by the fusion of a phagosome with a lysosome. Substances
within a phagolysosome are digested by hydrolysis.
phagosome
A phagocytic membrane-limited vesicle in a phagocyte
that contains phagocytized material that is digested by
lysosomal enzymes that enter the vesicle after fusion with
lysosomes in the cytoplasm.
pharyngeal pouch
Embryonic structure in the neck that provides the thymus,
parathyroids, and other tissues with epithelial cells.
pharyngeal pouch syndrome
Thymic hypoplasia.
N
2
Phenylbutazone.
1
N
O
pharyngeal tonsils
Lymphoid follicles found in the roof and posterior wall of
the nasopharynx. They are similar to Peyer’s patches in the
small intestine. Mucosal lymphoid follicles are rich in IgAproducing
B cells that may be found in germinal centers.
(Phe,G)AL
A poly-l-lysine backbone to which side chains of phenylalanine
and glutamic acid short polymers are linked by
alanine residues.
phenotype
Observable feature of a cell or organism that results from
interaction between the genotype and the environment. A
phenotype represents genetically encoded characteristics
that are expressed. The term may also refer to a group of
organisms with the same physical appearance and the same
detectable characteristics.
phenylbutazone (4-butyl-1,2-diphenyl-3,5-pyrazolidenedione)
A drug that prevents synthesis of prostaglandin and serves
as a powerful anti-inflammatory agent. It is used in therapy
of rheumatoid arthritis and ankylosing spondylitis.
Philadelphia chromosome
Abbreviated chromosome 22 as a consequence of the
T(9;22)(q34;q11) reciprocal translocation leading to fusion
of the Bcr gene on chromosome 22 with the abl gene on
chromosome 9. The Bcr-abl fusion gene encodes a chimeric
protein that possesses constitutive Abl tyrosine kinase
activity as a consequence of abnormal regulation and oligomerization
capacity conferred by the Bcr moiety. Present
in CML and in selected ALL patients.
Phoma species
Aeroallergenic fungi that can induce hypersensitivity
pneumonitis (HP); one type is known as shower curtain
disease.
phorbol ester(s)
Esters of phorbol alcohol (4,9,12-β,13,20-pentahydroxy-
1,6-tigliadien-3-one) found in croton oil and myristic
acid. Phorbol myristate acetate (PMA), which is of interest
to immunologists, is a phorbol ester called 12-Otetradecanoylphorbol-13-acetate
(TPA). It is a powerful
tumor promoter that also exerts pleiotropic effects on
cells in culture, such as stimulation of macromolecular
6 7 8 9 10 11 12
13
14
2 3 4 5
19 20 21 22
15
16
Philadelphia chromosome.
17
18
X Y
P