Untitled - D Ank Unlimited

panel reactive antibody (PRA) test 550 P antigen
mAb against CD4
panel reactive antibody (PRA) test
A laboratory method designed to identify the level of
sensitization to potential donors in recipients awaiting organ
transplants. The recipient’s serum is screened for antibodies
reactive with panels of pooled cells that express a wide
spectrum of MHC molecules. PRA represents the percentage
of subjects in the panel with cells that interact with the
patient’s antibodies. The test is employed to detect preformed
alloantibodies in a recipient that could lead to hyperacute
rejection of tissue from selected allogeneic donors.
Paneth cells
Narrow, pyramidal, or columnar epithelial cells, with round or
oval nuclei near their bases, present in the fundi of the crypts
of Lieberkühn. They manifest large secretory granules that
may contain peptidase and produce antimicrobial proteins.
panning
A technique to isolate lymphocyte subsets through the use
of petri plates coated with monoclonal antibodies specific
for lymphocyte surface markers; thus, only lymphocytes
bearing the marker sought bind to the petri plate surface.
Cartilage
Bone
Pannus.
pannus
Granulation tissue reaction that is chronic and progressive
and produces joint erosion in patients with rheumatoid
arthritis. It is a structure that develops in synovial membranes
during the chronic proliferative and destructive
Add a
mixture
of CD4 + and
CD8 + T cells
CD8 +
CD4 +
Discard top layer
containing CD8 +
CD8 + CD4 + CD8 + CD4 +
Pannus
Tissue
destruction
at the
pannus margin
Panning technique.
Incubation
CD4 + T cells
remain in
petri plate
phase of rheumatoid arthritis. It is a membrane of granulation
tissue induced by immune complexes deposited in
the synovial membranes. They stimulate macrophages to
release interleukin-1, fibroblast-activating factor, prostaglandins,
substance P, and platelet-derived growth factor
which leads to extensive injury to chondro-osseous tissues.
The articular surface of the joint is covered by this synovitis.
Edema, swelling, and erythema in the joints are present,
in addition to palisades of histiocytes. This entire process
can fill the joint space, leading to demineralization and
cystic resorption.
pan-T cell markers
Surface epitopes found on all normal T lymphocytes. These
include the 50-kDa CD2 molecule that is the sheep erythrocyte
rosette marker found exclusively on T lymphocytes, the
41-kDa CD7 molecule, CD1 present on peripheral T lymphocytes
and cortical thymocytes, the mature T lymphocyte
marker CD3, and CD5.
P Antigen
Reactions with Anti- Phenotype Frequency
Phenotype P 1 P P k PP 1P k Caucasian
African
American
P 1 + + 0 + 79 94
P 2 0 + 0 + 21 6
P 0 0 0 0 Very rare
P k
1
P k
2
+
0
0
0
+
+
+
+
Very rare
Very rare
P antigen
An ABH-blood group-related antigen found on erythrocyte
surfaces and composed of three sugars (galactose,
N-isoacetyl-galactosamine, and N-acetyl-glucosamine).
The P antigens are designated P 1, P 2, P k , and P. P 2 subjects
rarely produce anti-P 1 antibody, which may lead
to hemolysis in clinical situations. Paroxysmal cold
hemagglutinaria patients develop a biphasic autoanti-P