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oxygen-independent killing 548 Oz isotypic determinant
the oxidative pathway. The oxidative mechanism kills
microbes through a complex process. Hydrogen peroxide
together with myeloperoxidase transforms chloride
ions into hypochlorous ions that kill microorganisms.
Azurophil granule fusion releases myeloperoxidase to
phagolysosomes. Some microorganisms such as pneumococci
form hydrogen peroxide.
oxygen-independent killing
Following adherence of opsonized microbes to neutrophil
plasma membranes, lysozyme and lactoferrin are discharged
from specific granules into phagosomes with which
they have fused. Antimicrobial cationic proteins reach
phagosomes from azurophil granules. These proteins kill
Gram-negative microbes by interrupting their cell membrane
integrity. They are far less effective against Grampositive
microorganisms.
Oz isotypic determinant
Oz represents an isotypic marker. λ Light chains of human
immunoglobulin that are Oz + contain lysine at position 190,
whereas those that are Oz – contain arginine at this position.
A fraction of each person’s λ light chains expresses
Oz – determinants.