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owl eye appearance 547 oxygen-dependent killing
Dr. Owen at work.
Owl eye appearance.
Cl
NADPH
C3b
receptor
Cl
C3b
IgG
receptor
IgG
H 2O 2
Oxidase
OH –
Cl
O 2 –
H 2O 2
owl eye appearance
Inclusions found by light microscopy in cytomegalovirus
(CMV) infection. CMV-infected epithelial cells are
enlarged and exhibit prominent eosinophilic intranuclear
inclusions that are half the size of the nucleus and are
encircled by a clear halo.
oxazolone (4-ethoxymethylene-2-phenyloxazol-5-one)
A substance used in experimental immunology to induce
contact hypersensitivity in laboratory animals.
oxidized low density lipoprotein (ox-LDL) autoantibodies
Autoantibodies against ox-LDL represent good markers
of LDL oxidation. Ox-LDL is immunogenic and leads to
increased immunoglobulin G (IgG) but not IgM or IgA
ox-LDL antibodies with carotid atherosclerosis. Ox-LDL antibodies
are also characterized as antiphospholipid antibodies,
whereas most antibodies against ox-LDL are specific for apolipoprotein
B epitopes, the major lipoprotein of LDL. A considerable
number are reactive against peroxidized phospholipid.
oxygen-dependent killing
Activated by a powerful oxidative burst that culminates
in the formation of hydrogen peroxide and other antimicrobial
substances. In addition to this oxygen-dependent
killing mechanism, phagocytized intracellular microbes
may be the targets of toxic substances released from granules
into phagosomes, leading to microbial cell death by
an oxygen-independent mechanism. For oxygen-dependent
killing of microbes, membranes of specific granules
and phagosomes fuse, permitting interaction of NADPH
oxidase with cytochrome. With the aid of quinone, this
combination reduces oxygen to superoxide anion O 2. In
the presence of a superoxide dismutase catalyst, superoxidase
ion is converted to hydrogen peroxide. The clinical
relevance of this process is illustrated by chronic granulomatous
disease (CGD) in children who fail to form
superoxide anions and have diminished cytochrome b,
even though phagocytosis is normal. They have impaired
ability to oxidize NADPH and destroy bacteria through
Cl
OH –
OH –
H 2O 2
Cl
–
O2 O 2 –
Bacterium
Cl
Cl
PMN
plasma
membrane
Formation of bactericide and hydrogen peroxide catalyzed by NADPH oxidase.
O