Untitled - D Ank Unlimited

Oudin, Jacques (1908–1986) 545 ovary autoantibodies
Nonidentity
reaction
Spur
(partial identity)
X
A, B
Anti
A, B, C
Line of
identity
and antibody diffuse through the gel medium, a line of
precipitation forms at the point of contact between antigen
and antibody. Results are expressed as a reaction of identity,
reaction of partial identity, or reaction of nonidentity (refer
to those entries for further details).
Oudin, Jacques (1908–1986)
French immunologist who was director of analytical immunology
at Institut Pasteur in Paris. His accomplishments
include discovery of idiotypy and the agar single-diffusionmethod
antigen–antibody assay.
Oudin test
A type of precipitation in gel that involves single diffusion.
Antiserum, incorporated into agar, is placed in a narrow
C
Ouchterlony test.
Gel precipitation using Ouchterlony technique.
Antigens
1, 2, 3
Antiserum
containing
anti-1, 2, 3
antibodies
Single diffusion in one dimension
A
3 Bands of
precipitation
formed by
Ag-Ab
interaction
test tube and overlaid with an antigen solution that diffuses
into the agar to yield precipitation rings. Also called single
radial diffusion test. A band of precipitation forms at the
equivalence point.
outbreeding
Mating of subjects who show greater genetic differences
between themselves than randomly chosen individuals of
a population. This process encourages genetic diversity, in
contrast to inbreeding and random breeding.
ovalbumin (OA)
A protein derived from avian egg albumin (egg white) used
extensively as an antigen in experimental immunology.
ovary antibodies (OAs)
Antibodies present in 15 to 50% of premature ovarian
failure patients in whom ovarian function failed after
puberty but prior to 40 years of age. These individuals have
elevated levels of gonadotropins in serum but diminished
serum estradiol levels. Premature ovarian failure is associated
with an increased incidence of autoimmune disease,
especially of the thyroid. Patients also develop autoantibodies
of both the organ-specific and nonorgan-specific types.
They are often HLA-DR3 positive and have elevated CD4/
CD8 ratios. Ovarian antibodies are specific for steroid cells,
which causes them to cross react with steroid-synthesizing
cells in the placenta, adrenals, and testes.
ovary autoantibodies
Autoantibodies to adrenal glands, ovary, placenta, and
testes are known as steroid cell autoantibodies. Adrenal
gland steroid autoantibodies commonly react with ovary
and testes antigens. Most females with Addison’s disease
and amenorrhea with autoimmune gonadal failure develop
Oudin test.
Lines of
precipitation
Antigens
1, 2, 3
Plain
gel medium
Antiserum
containing
anti-1, 2, 3
antibodies
Oudin test.
Double diffusion in one dimension
Soluble
antigen
Antiserum
3 Bands of
precipitation
formed by
Ag-Ab
interaction
O