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Nuttall, George H.F. (1862–1937) 538 NZB/NZW F 1 hybrid mice
George H.F. Nuttall.
Nuttall, George H.F. (1862–1937)
Author of a landmark publication titled Blood Immunity
and Blood Relationship. He was an early pioneer in comparative
immunology.
nylon wool
A material used to fractionate T and B cells from a mixture
based on the tendency for B cells to adhere to nylon wool,
while T cells pass through it. B cells are then eluted from
the column. Tissue typing laboratories previously used this
technique to isolate B lymphocytes for major histocompatibility
complex (MHC) class II (B cell) typing. Magnetic
beads have replaced nylon wool for lymphocyte T and B
cell separation.
Syringe
Test tube
Nylon wool.
Nylon wool
B lymphocytes
Separation of
T and B lymphocytes
(T cells pass through)
T lymphocytes
NZB/NZW F 1 hybrid mice
A mouse strain genetically prone to develop lupus erythematosus
(LE)-like disease spontaneously. This was the first
murine lupus model and was developed from the NZB/
B l mouse model of autoimmune hemolytic anemia mated
with the NZW mouse, which develops a positive Coombs’
test, antinuclear antibodies, and glomerulonephritis. This
F 1 hybrid develops various antinuclear autoantibodies and
forms immune complexes that subsequently induce glomerulonephritis
and shorten life spans due to renal disease.
Hemolytic anemia is minimal in the F 1 strain compared to
the NZB parent. NZB mice show greater lymphoid hyperplasia
than do the F 1 hybrids, yet the latter show features
that are remarkably similar to those observed in human
lupus, such as major sex differences.