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N-formyl peptide receptor (FPR) 527 neopterin
antibody specific for outer membrane proteins that can be
used to induce immunity.
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N-formyl peptide receptor (FPR)
A member of the G protein coupled receptor family, the
chemokine receptor branch of the rhodopsin family. Tissue
sources include HL-60 cells differentiated with Bt2 cAMP.
Undifferentiated HL-60 cells transfected with FPR bound
FMLP with two affinities. COS7 cells transfected with
FPR bound FMLPK-Pep12 with low and high affinity.
The receptor is expressed in neutrophils. Dibutyryl cAMP
includes FPR transcription in HL-60 cells.
neoantigen
Modification of proteins by phosphorylation or specific
proteolysis may change their covalent architecture to yield
new antigenic determinants or epitopes termed neoantigens;
a neoantigen is also an epitope newly expressed on cells
during development or in neoplasia. Neoantigens include
tumor-associated antigens. New antigenic determinants
may also emerge when a protein changes conformation or
when a molecule is split, exposing previously unexpressed
epitopes. A neoantigen may be produced by the union of a
xenobiotic with a self protein.
neonatal Fc receptor (FcRn)
An Fc receptor is specific for immunoglobulin G (IgG) that
facilitates the transport of maternal IgG across the placenta
and the neonatal intestinal epithelium. FcRn is similar to a
class I molecule. An adult variety of this receptor protects
plasma IgG antibodies from catabolism.
neonatal immunity
Resistance in the newborn attributable to maternal circulating
antibodies that reached the fetus via the placenta or
maternal secretory antibodies translated to the newborn in
breast milk. The quality and quantity of both humoral and
cellular immune responses of neonates differ from those
of adults. These differences may be a consequence of the
lower incidence and decreased function of immunocompetent
cells, such as B cells, T cells, and antigen-presenting
cells early in ontogeny. Restriction of T and B cell function
early in ontogeny compared with function in the adult may
be due partially to limitations in the diversity of antigenspecific
repertoires. Differences in responses to various
types of activation by neonatal and adult lymphocytes also
affect immunity. A type of passive immunization.
neonatal thymectomy syndrome
Refer to wasting disease.
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H . CH 3SO 3H
Nelfinavir mesylate (Viracept). A powerful HIV-1 protease inhibitor,
effective orally, used together with HIV reverse transcriptase inhibitors to
treat HIV infection.
neonatal tolerance
The concept that immunologic tolerance to an antigen is
established more easily in neonates than in mature animals.
Attributable to functional immaturity and decreased
numbers of neonatal T and B lymphocytes, dendritic cells,
macrophages, and follicular dendritic cells, as well as modified
patterns of lymphocyte recirculation.
Cancer cell
SLe*
E-selectin
P-selectin
SLe*
Platelet
SLe*
E-selectin
P-selectin
SLe*
CD44
ICAM-1
Tumor cell attached through E-selectin molecules to endothelial cell
surface.
ICAM-1
Leukemia cell
CD44
LFA-1
E-selectin
SLe
VCAM-1
ICAM-1
VLA-4
Leukemia cell attached to endothelial cell surface via adhesion molecules.
neoplasm
Any new and abnormal growth that may be a benign or
malignant tumor.
neopterin
A guanosine triphosphate metabolite synthesized by macrophages
following their stimulation by interferon-γ (IFN-γ)
from activated T lymphocytes. Neopterin levels in both
serum and urine of patients infected with HIV-1 rise as the
infection progresses. The increase in neopterin along with
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