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myelin basic protein (MBP) 519 myelodysplastic syndromes (MDS)
Myelin membrane adhesion molecule.
myelin basic protein (MBP)
A principal constituent of the myelin lipoprotein that first
appears during late embryogenesis. It is a 19-kDa protein
that is increased in multiple sclerosis patients who may generate
T lymphocyte reactivity against MBP. T lymphocytes
with the Vβ-17 variant of the T cell receptor are especially
prone to react to MBP.
Encephalitogenic
site
Homologous region
8 Amino acid
oligopeptide
Myelin
basic
protein
Hepatitis B
virus polymerase
Myelin basic protein (MBP).
myelin basic protein (MBP) antibodies
Antibodies against myelin proteins have been investigated
for their possible role in the demyelination that accompanies
multiple sclerosis, acute idiopathic optic neuritis, Guillain–
Barré syndrome, chronic relapsing polyradiculoneuritis,
carcinomatous polyneuropathy, and subacute sclerosing
panencephalitis. Antibodies against myelin basic protein
are well known to play a role in experimental allergic
encephalomyelitis in laboratory animals, but the role they
play in patients with multiple sclerosis and other neurological
diseases has yet to be established. MBP autoantibody
titers are closely correlated with exacerbations and relapses
in MS and are present in 75% of MS patients and 89% of
optic neuritis subjects. They have also been detected in 64%
of HIV-associated neurological syndrome cases, in 58% of
autistic children, in 30% of Japanese encephalitis cases, and
in 30% of patients with subacute sclerosing panencephalitis
(SSPE). Humoral and cellular immune responses participate
in inflammatory demyelination.
myeloablative conditioning
A type of therapy required prior to bone marrow transplantation
in which a patient’s hematopoietic cells in the bone marrow
are eliminated through the use of aggressive chemotherapy
and total body irradiation, causing depletion of immune system
cells from both the peripheral blood and the secondary lymphoid
tissues. This therapy is used before hematopoietic cell
transplantation and bone marrow transplantation.
myeloblast
A myeloid lineage immature hematopoietic cell produced by
and present in the bone marrow but not usually found in the
peripheral blood. It leads to the formation of granulocyte
precursors and possesses nongranular basophilic cytoplasm.
myelodysplastic syndromes (MDS)
Category of hematopoietic disorders characterized by
increased infection, anemia, and hemorrhage. The disorders
Anti-HBVP
Antibodies
Cytoxic T-cell
causing
demyelinating disease
M