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monogamous multivalency 508 monomers
Therapeutic Monoclonal Antibodies and Their Potential Clinical Uses
Monoclonal Antibody Condition Treated or Prevented
Abciximab (c7E3 Fab), specific for platelet
glycoprotein 11b-111a receptors
Adjunct to percutaneous coronary intervention
to prevent cardiac ischemic complications
Alemtuzumab (Campath-1H), anti CD52 B cell chronic lymphocytic leukemia
Antimyosin MAb (Octreoscan ® ), indium 111 labeled Cardiac scintigraphy
Anti-CD66 (a,b,c,e) MAb (Basiliximab), rhenium 188
labeled
Conditioning for stem cell transplantation
Basiliximab Acute organ rejection
Bectumomab B cell lymphomas and leukemias
Capromab pendetide (indium 111 labeled) Immunoscintigraphy
Daclizumab Acute organ rejection
Edobacomab Gram-negative bacterial endotoxins
Endrecolomab Solid tumors (e.g., colorectal carcinoma)
Enlimomab (anti-ICAM-1) Organ transplant rejection
Felvizumab Respiratory syncytial virus
Gemtuzumab ozogamicin (Mylotarg ® ), anti-CD33 Acute myeloid leukemia
Ibritumomab tiuxetan, anti-CD20, yttrium 90 labeled Non-Hodgkin B cell lymphoma
Infliximab (anti-TNFα) Crohn’s disease; rheumatoid arthritis
Inolimomab (anti-IL2 receptor) Organ transplant rejection
Iodine 131 Tositumomab Non-Hodgkin B cell lymphomas
Muromonab-CD3 Acute allograft rejection
Nebacumab (Centoxin ® ) Anti-Gram-negative bacterial endotoxins
OKT3 (anti-CD3) Organ transplant rejection
Olizumab (anti-IgE) Allergic asthma; allergic rhinitis
Omalizumab (anti-IgE) Allergic asthma; allergic rhinitis
Omalizumab (anti-IgE) Allergic asthma; allergic rhinitis
Palivizumab Respiratory syncytial virus
Priliximab (anti-CD4) Heart transplant rejection; mycosis fungoides
RhuMAbVEGF Solid tumors
Rituximab (anti-CD20) CD20+ non-Hodgkin B cell lymphoma
Satumomab pendetide (indium labeled) Diagnostic imaging; immunoscintigraphy
Tc-99m anti-CD15 (Acutect ® ), antineutrophil Imaging agent for diagnosis of infection
Transtuzumab (anti-p185-HER2) Metastatic breast cancer
Votumumab, Tc-99m radiolabeled Cancer imaging agent
Zolimomab aritox (anti-CD5–ricin A chain toxin) Graft-vs.-host disease
16–22 µm.
Monocyte.
for easy interaction with an adjacent identical epitope.
Interaction of this type represents high affinity of binding,
which lends a stability to the antigen–antibody complex.
The combination of one IgM molecule to multiple epitopes
on a single molecule of antigen would represent monogamous
multivalency.
monogamous multivalency
Refer to monogamous bivalency.
monokine
A cytokine produced by monocytes. Any one of a group
of biologically active factors secreted by monocytes and
macrophages that have a regulatory effect on the functions
of other cells such as lymphocytes. Examples include
interleukin-1 (IL1) and tumor necrosis factor (TNF).
monomers
(1) Subunits of an immunoglobulin molecule; two heavy
and two light chains that comprise the four polypeptide
chains of a typical IgG molecule. (2) Also used to refer
to a basic four-chain monomer or monomeric unit of an
immunoglobulin molecule. In contrast to one monomeric