Untitled - D Ank Unlimited

monoclonal immunoglobulin 506 monoclonal immunoglobulin
Thcrapeutic Monoclonal Antibodies
Antibody Name Target Antigen Conditions Treated and/or Prevented
Muromonab (Orthoclone OKT3) CD3 Allograft rejection
Natalizumab (Antegren) α-4 Integrin (VLA-4) Multiple sclerosis, Crohn’s disease
Nebacumab (Centoxin) Bacterial endotoxins Gram-negative bacteria sepsis
Nofetumomab (Verluma) Carcinoma-associated antigen Detection of small cell lung cancer
OctreoScan, indium 111 labeled Somatostatin receptor Immunoscintigraphic localization of
primary and metastatic neuroendocrine
tumors containing somatostatin
receptors
Olizuma, rhuMAb-E25 Ig-E Allergic asthma, allergic rhinitis
Oncolym (131Lym-1), iodine 131 labeled HLA-DA B cell non-Hodgkin lymphoma
Omalizumab (Xolari) IgE Allergic asthma, allergic rhinitis
Oregovomab (OvaRex) Tumor-associated antigen CA125 Ovarian cancer
Orthoclone OKT4A CD4 CD4-mediated autoimmune diseases,
allograft rejection
Palivizumab (Synagis) Antigenic site of F protein of respiratory
syncytial virus
Respiratory syncytial virus infection
Pexelizumab (5G1.1-SC) Complement C5 AMI, UA, CPB, PTCA
Priliximab CD4 Crohn’s disease, multiple sclerosis
Regavirumab Cytomegalovirus Acute CMV disease
Rituximab (Rituxan) CD20 Non-Hodgkin lymphoma
Satumomab pendetide (OncoScint CR/OV) Tumor-associated glycoprotein-72 Detection of colorectal and ovarian
cancers
Sevirumab (Protovir) Cytomegalovirus Prevention of CMV infection in bone
marrow transplant patients
Siplizumab (MEDI-507) CD2 Acute GVHD, psoriatic arthritis
Smart M195 CD33 Acute myeloid leukemia,
myelodysplastic syndrome
Sulesomab (LeukoScan), technetium 99m labeled Surface granulocyte nonspecific crossreacting
antigen
Tecnemab K1 (withdrawn from market) High molecular weight melanoma-associated
antigen
Detection of osteomyelitis, acute
atypical appendicitis
Diagnosis of cutaneous melanoma
lesions
Tositumomab (Bexxar), iodine 131 attached B cell surface protein Non-Hodgkin lymphoma
Trastuzumab (Herceptin) Her2/neu Her2-positive metastatic breast cancer
Visilizumab (Nuvion, Smart, anti-CD3) CD3 GVHD, ulcerative colitis
Vitaxin αvβ3 Integrin Solid tumors
Votumumab (Humaspect) Cytokeratin tumor-associated antigen Detection of carcinoma of colon and
rectum
YM-337 GPIIb/IIIa Prevention of platelet aggregation
Zolimomab
AFP = α α fetoprotein.
AMI = acute myocardial infarction.
CPB = cardiopulmonary bypass.
EGFR = epidermal growth factor receptor.
GPIIb/IIIa = glycoprotein IIbIIIa.
GVHD = graft-vs-host disease.
HLA = human leukocyte antigen.
ICAM-1 = intercellular adhesion molecule-1.
IL-2 = interleukin-2.
IL-8 = interleukin-8.
PTCA = percutaneous transluminal coronary angioplasty.
TGFb2 = transforming growth factor b2.
TNF-α = tumor necrosis factor α.
UA = unstable angina.
VEGF = vascular endothelial growth factor.
VLA-4 = very late antigen-4.
CD5, ricin, A chain toxin GVHD