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Untitled - D Ank Unlimited

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monoclonal immunoglobulin 505 monoclonal immunoglobulin<br />

Thcrapeutic Monoclonal Antibodies<br />

Antibody Name Target Antigen Conditions Treated and/or Prevented<br />

Abciximab (ReoPro) Glycoprotein IIb and IIIa receptor Complications of coronary angioplasty<br />

ABX-CBL CD147 GVHD<br />

ABX-EGF EGFR EGF-dependent human tumor<br />

ABX-IL8 IL8 Rheumatoid arthritis, psoriasis<br />

AcuTect Diagnosis of acute venous thrombosis<br />

Adalimumab (Humira) TNF Rheumatoid arthritis<br />

AFP-Scan AFP Detection of liver and germ cell cancers<br />

Alemtuzumab (Campath) CD52 B cell chronic lymphocytic leukemia,<br />

multiple sclerosis, kidney transplant<br />

rejection<br />

Apolizumab (Remitogen) 1D10 antigen B cell non-Hodgkin lymphoma, solid<br />

tumors<br />

Arcitumomab (CEA-Scan), technetium 99m labeled Carcinoembryonic antigen Detection and location of recurrent and<br />

metastatic colorectal cancer<br />

Anti-CD11a hu1 124 CD11a Psoriasis<br />

Basiliximab (Simulect) CD25 (IL2 receptor) Allograft rejection<br />

Bectumomab Non-Hodgkin lymphoma<br />

Bevacizumab (Avastin) VEGF Metastatic renal carcinoma<br />

Capromab Pendetide (Prostascint), indium 111 labeled Prostate membrane-specific antigen Radioimmunoscintigraphy for prostate<br />

cancer<br />

Cetuximab EGFR Head and neck, breast, pancreatic,<br />

colorectal cancers<br />

CEACide Carcinoembryonic antigen<br />

Daclizumab (Zenapax) CD25 (IL2 receptor) Allograft rejection<br />

Edrecolomab (Panorex) 17-1A cell surface antigen Colorectal cancer<br />

Efalizumab (Xanelim) CD11a Rheumatoid arthritis<br />

Enlimomab CD54 (ICAM-1) Organ transplant rejection<br />

Epratuzumab (LymphoCide) CD22 Non-Hodgkin lymphoma<br />

Gemtuzumab ozogamicin (Mylotarg) CD33 calicheamicin Acute myeloid leukemia<br />

Hu23F2G (LeukArrest) CD11/18 (leukointegrin) Ischemic stroke<br />

Hu1124 CD11a Psoriasis<br />

Ibritumomab tiuxetan (Zevalin) CD20 B cell non-Hodgkin lymphoma<br />

Igovomab (Indimacis 125) Tumor-associated antigen CA125 Detection of ovarian adenocarcinoma<br />

Imciromab pentetate (Myoscint) Human cardiac myosin Myocardial infarction imaging<br />

IMC-C225 (Erbitux) EGFR EGF-dependent human tumor<br />

Infliximab (Remicade) TNF-α Crohn’s disease, rheumatoid arthritis<br />

Inolimomab IL2 receptor Organ transplant rejection<br />

LDP-01 β2 integrin Stroke, kidney transplant rejection<br />

LDP-02 α4β7 Integrin receptor Crohn’s disease, ulcerative colitis<br />

LeuTech 99cTc-anti-CD15 anti-granulocyte antibody CD15 Imaging infection sites<br />

Lerdelimumab TGFb2 Glaucoma, cataract<br />

Lym-1, yttrium 90 labeled HLA-DR Non-Hodgkin lymphoma<br />

Lymphoscan CD22 Detection of B cell non-Hodgkin<br />

lymphoma<br />

MAK-195F TNFα Hyperinflammatory response in sepsis<br />

syndrome<br />

MDX-33 CD64 Idiopathic thrombocytopenic purpura<br />

MCX-H210 Bispecific HER2 x CD64 Breast, colorectal, kidney, ovarian, and<br />

prostate cancers<br />

MDX-447 Bispecific EGFR x CD64 Head, neck, and renal cancers<br />

Mitumomab (BEC2) GD3 idiotypic Small cell lung cancer, melanoma<br />

(Continued)<br />

M

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