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mixed agglutination 500 mixed lymphocyte culture (MLC)
mixed agglutination
Aggregation (agglutination) produced when morphologically
dissimilar cells that share a common antigen are reacted with
antibody specific for this epitope. The technique is useful in
demonstrating antigens on cells that by virtue of their size or
irregular shape are not suitable for study by conventional agglutination
tests. It is convenient to use an indicator, such as a red
cell, that possesses the antigen sought. Thus, the demonstration
of mixed agglutination in which the indicator cells are linked to
the other cell type suspected of possessing the common antigen
constitutes a positive test.
mixed antiglobulin reaction
A test to demonstrate antibodies adsorbed to cell surfaces.
The addition of antiglobulin-coated red cells to a suspension
of cells suspected of containing cell surface antibodies
results in formation of erythrocyte–test cell aggregates if
the test is positive. This is caused by linkage of the antiglobulin
to the immunoglobulin on the surfaces of test cells.
mixed chimerism
In a non-myeloablative conditioned hematopoietic cell
transplant recipient who has received a donor cell infusion,
Responder
lymphocytes
from the spleen
Strain A
Addition
of
( 3 H thymidine)
Harvest cells from
microwell culture
into a filter-paper
strip
Count ( 3 H)
incorporated
into the DNA
the recipient’s surviving hematopoietic stem cells coexist
with donor hematopoietic stem cells and yield cells of the
myeloid and lymphoid lineages.
mixed connective tissue disease (MCTD)
A connective tissue disease that shares characteristics in common
with systemic lupus erythematosus (SLE), rheumatoid
arthritis (RA), and dermatomyositis. Under immunofluorescence,
a speckled nuclear pattern attributable to antinuclear
antibody in the circulation is revealed. The titers of antinuclear
antibodies specific for nuclear ribonucleoproteins are high.
Treatment with corticosteroids is very effective. Also called
Sharp syndrome or overlap syndrome.
mixed hemadsorption
The demonstration of antiviral antibody by the mixed antiglobulin
reaction.
mixed leukocyte reaction (MLR)
Refer to mixed lymphocyte reaction.
mixed lymphocyte culture (MLC)
The combination of lymphocytes from two members of a
species in culture where they are maintained and incubated
for 3 to 5 days. Lymphoblasts are formed as a consequence
Stimulator lymphocytes
from the spleen
Treat with X-rays
or mitomycin C
4-day incubation
in microwell culture
18–24 hour
incubation period
Mixed lymphocyte reaction (MLR).
Strain B