Untitled - D Ank Unlimited

MIP-2 (macrophage inflammatory protein 2) 498 mitochondrial autoantibodies (MAs)
MIP-1β exert synergistic HIV-suppressive effects. Tissue
sources include monocytes, fibroblasts, T lymphocytes, B
lymphocytes, neutrophils, smooth muscle cells, mast cells,
and selected tumor cell lines. Monocytes, T lymphocytes,
hematopoietic precursor cells, and basophils are target cells.
MIP-2 (macrophage inflammatory protein 2)
A chemokine of the α (CXC) family. The MIP-2 class is
comprised of MIP-2α, also termed GRO-β gene product,
and MIP-2β, the GRO-γ gene product. MIP-2 has a role in
anti-GBM antibody-induced glomerulonephritis in mice. Anti-
MIP-2 antibody injection 30 minutes before anti-GBM antibody
effectively decreases neutrophil influx and PAS-positive
deposits containing fibrin. Tissue sources include mast cells,
cardiac myocytes, mesangial cells, alveolar macrophages,
epidermal cells, human nasal, and bronchial epithelium.
Neutrophils, basophils, and epithelial cells are the target cells.
MIRL (membrane inhibitor of reactive lysis)
Inhibitor of membrane attack complexes on self tissue. Also
known as CD59.
missing self hypothesis
The hypothesis that interaction of NK cells with cells failing
to express self MHC class I antigens on their surfaces
leads to T cell activation. Examples include neoplastic cells;
virus-infected cells; and allogeneic cells.
N.A. Mitcheson.
Mitcheson, N.A. (1928–)
British investigator who demonstrated the role of helper T
cells in immunoregulation.
mitochondria
Cytoplasmic organelles in aerobic eukaryotic cells where
respiration, electron transport, oxidative phosphorylation,
and citric acid cycle reactions occur. Mitochondria possess
DNA and ribosomes.
mitochondrial antibodies
Immunoglobulin G (IgG) antibodies present in 90 to 95% of
primary biliary cirrhosis (PBC) patients. These antibodies,
which are of doubtful pathogenic significance, are specific
for the pyruvate dehydrogenase enzyme complex E2
component situated at the inner mitochondrial membrane
(M2). They are also specific for another E2-associated
protein. Other antimitochondrial antibodies include the M1
Mitochondrial autoantibodies.
Mitochondrial antibody (mouse kidney, 500× magnification).
Mitochondrial autoantibodies (mouse kidney and stomach).
antibodies of syphilis, the M3 antibodies found in pseudolupus,
the M5 antibodies in collagen diseases, the M6 antibodies
in hepatitis induced by iproniazid, the M7 antibodies
associated with myocarditis and cardiomyopathy, the M8
antibodies that may be markers for prognosis, and the M9
antibodies that serve as markers for beginning primary
biliary cirrhosis. Mitochondrial antibody titer may be an
indicator of primary biliary cirrhosis progression. A patient
with a titer of 1 to 40 or more should be suspected of having
primary biliary cirrhosis, whether symptoms are present or
absent and even if alkaline phosphatase is normal.
mitochondrial autoantibodies (MAs)
Immunoglobulin G (IgG) autoantibodies specific for the
E2 component (lipoate acetytransferase) of the pyruvate
dehydrogenase enzyme complex located at the inner