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MiHA 496 Miller–Fisher syndrome (MFS)
Peter Miescher.
Live cells
lymphokine-activated macrophages. IFN-γ can induce macrophages
to express the MIG gene. Tissue sources include
lymphokine-activated macrophages, IFN-γ-treated human
peripheral blood monocytes, and IFN-γ-treated human
monocytic cell line THP-1. Target cells include human
tumor-infiltrating lymphocytes (TILs) and monocytes.
MiHA
Refer to minor histocompatibility antigens.
MIICs
MHC class compartments or class II vesicles. These
specialized late endosomal spaces comprise a segment
of the exogenous (endocytic) antigen processing pathway.
Endolysosomal MHC-CLIP complexes enter MIICs where
CLIP exchange and peptide loading occur.
Mikulicz’s syndrome
Lymphocytic inflammation in the parotid gland. This condition
represents a type of Sjögren’s syndrome.
Milgrom, Felix (1919–2007)
Polish-American investigator who worked at the University
of Buffalo in New York State. He and Ernest Witebsky
described anti-immunoglobulin antibodies. They immunized
rabbits with aggregated autologous globulin and
discovered that the rabbits produced antibodies with greater
reactivity for human globulin than for rabbit globulin.
Miller, J.F.A.P. (1931–)
Proved the role of the thymus in immunity while investigating
Gross’ leukemia in neonatal mice.
Miller–Fisher syndrome (MFS)
A variant of Guillain–Barré syndrome (GBS) that has a
subacute onset and follows infectious illnesses of which
Live cells Dead cells All cells dead
Microlymphocytotoxicity.
Felix Milgrom.
J.F.A.P. Miller.
Campylobacter jejuni infection is the most common. Fewer
than 5% of GBS cases have MFS. Clinically, MFS presents
as ophthalmoplegia, ataxia, and areflexia. The extremity and
trunk muscles exhibit little or no weakness. The spinal fluid
protein is seldom increased, and nerve conduction studies are
usually normal. Most MFS patients have circulating polyclonal
antibodies to GQb1 ganglioside, a minor ganglioside component
of both the central and peripheral nervous systems. These
antibodies are highest initially and fall with recovery.