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microtiter technique 495 MIG
The separation of lymphocytes from peripheral blood by centrifugation
using Ficoll-Hypaque.
A Hamilton syringe that is used to dispense lymphocytes into Terasaki
plates for tissue typing.
A Terasaki plate consisting of depressions in a plastic plate that contains predispensed
antibodies to HLA antigens of various specificities and into which
are placed patient lymphocytes and rabbit complement for tissue typing.
An inverted light microscope used to read Terasaki plates to determine
tissue type.
microtiter technique
Refer to Takatsy method.
microtubules
These organelles are hollow, cylindrical fibers about 240 Å
in diameter, radiating from the centers of eukaryotic cells,
including lymphocytes, phagocytes, and mast cells, in all
directions toward plasma membranes. Mitotic spindles are
composed of microtubules. They form a sturdy cytoskeleton.
They originate from centrioles, structures occupying
the concavities of nuclei. Microtubules provide orientation
of gross membrane activities, associate directly or indirectly
with granules to enable their contact and fusion with endocytic
vesicles, and direct reorganization of cell membranes.
Although not critical for the cell movement of chemotaxis,
they are needed for “fine tuning” of cell locomotion. Their
major component is tubulin, a dimeric protein.
mid-piece (historical)
A term used by investigators in the early 1900s to refer to
components of complement present in the serum euglobulin
fraction that actually contains the entire C1 and selected
other complement components, but no C2 component.
Miescher, Peter (1923–)
Swiss physician, authority on autoimmune diseases, and
prolific author of research articles about them.
MIF
Macrophage–monocyte migration inhibitory factor. A
substance synthesized by T lymphocytes in response to
immunogenic challenge that inhibits the migration of
macrophages. MIF is a 25-kDa lymphokine. Its mechanism
of action is by elevating intracellular cAMP, polymerizing
microtubules, and stopping macrophage migration. MIF
may increase the adhesive properties of macrophages,
thereby inhibiting their migration. The two types of protein
MIF include one of 65 kDa with a pI of 3 to 4 and another
of 25 kDa with a pI of approximately 5.
mIg
Abbreviation for membrane-bound immunoglobulin.
MIG
Monokine induced by interferon-γ (IFN-γ) is a chemokine of
the α (CXC) family. It is derived from a cDNA library from
M