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MART-1 (M2-7C10), mouse 480 mast cells
John Richardson Marrack.
Marsupial.
the placenta, most of the transfer of maternal antibodies
begins with suckling and continues until the young leave
the pouch, at which time immune competence is fully
developed. Adult marsupials possess lymphoid organs that
participate in both humoral and cellular immune responses.
Some data suggest that the humoral immune response may
be initially sluggish and that selective immune responses
may be refractory to certain cytokines.
MART-1 (M2-7C10), mouse
A melanocyte differentiation antigen present in melanocytes
of normal skin and retina, nevi and in more than 85% of
melanomas. This antibody is very useful in establishing the
diagnosis of metastatic melanoma. Also known as melan A.
mass vaccination
Immunization with vaccines during an outbreak of a communicable
disease in an effort to prevent an epidemic. For
example, mass vaccinations may be carried out in schools
and hospitals during meningitis or hepatitis epidemics.
mast cell activation
Mast cells may be activated immunologically through cross
linking by antigen of surface immunoglobulin E (IgE)
attached to FcεRI. They may be activated also by anti-IgE
antibody, C5a, substance P, or local trauma.
mast cell–eosinophil axis
Interactions between mast cells and eosinophils during inflammatory
reactions recognized as immediate hypersensitivity.
This involves the attraction of eosinophils and their activation
by mast-cell-derived ECF-A along with a dampening effect
exerted by eosinophils upon mast cells. The released mediators
influence the reactions in the microenvironment. When the
causative agent is a parasite, the antiparasitic cytotoxic mechanisms
of eosinophils reinforce the defense. The other effector
cells attracted to the involved sites join forces in the defense
activities. The inhibitory effects of eosinophils upon mast
cells are exerted through a number of enzymes that inactivate
or destroy some of the mast-cell-derived mediators. Intact
granules released from mast cells in the microenvironment are
phagocytized by eosinophils and can be demonstrated in these
cells by metachromatic staining. This represents an important
detoxification mechanism, as even intact granules have been
shown to exert proteolytic activity.
mast cell growth factor 1
Synonym for interleukin-3 (IL3).
10–15 µm
Mast cell.
Mast cell.
mast cell growth factor 2
Synonym for interleukin-4 (IL4).
mast cells
A normal component of connective tissue that plays an
important role in immediate (type I) hypersensitivity and
inflammatory reactions by secreting a large variety of chemical
mediators from storage sites in their granules upon stimulation.
Mast cells possess high-affinity Fcε receptors (Fcε RI)
that bind free IgE. Their locations at mucosal and cutaneous
surfaces and about venules in deeper tissues is related to
this role. They can be identified easily by their characteristic
granules that stain metachromatically. The sizes and shapes
of mast cells vary in diameter (10 to 30 μm). In adventitia of
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