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macrophage inflammatory protein 1β(MIP-1β) 475 macrophage migration inhibitory factor
MIP-1α (NMR).
Macrophage inflammatory protein 1α.
endotoxin may secrete this protein, termed MIP-1, which
differs from tumor necrosis factor (TNF), interleukin-1
(IL1), and other endogenous pyrogens because its action
is not associated with prostaglandin synthesis. It appears
indistinguishable from hematopoietic stem cell inhibitor
and may function in growth regulation of hematopoietic
cells. It has a broad spectrum of biological activities
that include prostaglandin-independent pyrogenic activity,
possible participation in wound healing, monocyte
chemotaxis, and suppression of immature bone marrow
Normal
cells
Ovalbumin–
sensitive
cells
Toxoid–
sensitive
cells
COOH
stem and progenitor cells. Significantly, MIP-1α has an
HIV-suppressive effect. Tissue sources include fibroblasts,
monocytes, lymphocytes, neutrophils, eosinophils, smooth
muscle cells, mast cells, platelets, and bone marrow stromal
cells, among other cell types. T lymphocytes, basophils,
hematopoietic precursor cells, monocytes, eosinophils, neutrophils,
mast cells, natural killer (NK) cells, and dendritic
cells, among other types, are target cells.
macrophage inflammatory protein 1(MIP-1)
A chemokine of the β (CC) family. It shares 70% homology
with MIP-1α. Although the two molecules resemble
one another structurally, they are significantly different in
functions. Unlike MIP-1α, MIP-1β does not activate neutrophils.
Unlike MIP-1α, which inhibits early hematopoietic
progenitor growth, MIP-1β potentiates it. Both MIP-1α
and MIP-1β exert synergistic HIV-suppressive effects.
Tissue sources include monocytes, fibroblasts, T lymphocytes,
B lymphocytes, neutrophils, smooth muscle cells,
mast cells, and selected tumor cell lines. Monocytes, T
lymphocytes, hematopoietic precursor cells and basophils
are target cells.
macrophage inflammatory protein-2 (MIP-2)
A chemokine of the α (CXC) family. The MIP-2 class is
comprised of MIP-2α, also called GRO-β gene product,
and MIP-2β, the GRO-γ gene product. MIP-2 has a role in
anti-GBM antibody-induced glomerulonephritis in mice.
Anti-MIP-2 antibody injection 30 minutes before anti-GBM
antibody effectively decreases neutrophil influx and PAS
positive deposits containing fibrin. Tissue sources include
mast cells, cardiac myocytes, mesangial cells, alveolar
macrophages, epidermal cells, and nasal and bronchial
epithelium. Neutrophils, basophils, and epithelial cells are
the target cells.
macrophage migration inhibitory factor
Migration inhibitory factor.
No antigen Ovalbumin Toxoid
A B
D
G
E F
H I
Macrophage migration test.
C
M