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lymphoblast 463 lymphocyte
Subcapsular sinus lymph node.
normally occupied by that cell population. The lymph
node acts as a filter and may be an important site for
phagocytosis and the initiation of immune responses.
lymphoblast
A relatively large cell of lymphocyte lineage that bears
a nucleus with fine chromatin and basophilic nucleoli.
Induced within 18 to 24 hours following engagement of resting
lymphocytes’ TCRs or BCRs. They frequently form following
antigenic or mitogenic challenge of lymphoid cells,
which leads to enlargement and division to produce effector
lymphocytes that are active in immune reactions. They
divide rapidly and differentiate into memory and effector
lymphocytes. The Epstein–Barr virus (EBV) is commonly
used to transform B cells into B lymphoblasts in tissue
culture to establish B lymphoblast cell lines. Lymphoblasts
have increased rates of synthesis of RNA and protein.
12–15 µm
Lymphoblast.
lymphoblastic leukemia
A malignancy that is a consequence of T or B precursor
cell transformation.
lymphocyte
A round cell that measures 7 to 12 μm and contains a round
to ovoid nucleus that may be indented. The chromatin is
densely packed and stains dark blue with Romanowsky
stain. Small lymphocytes contain a thin rim of robin’s egg
blue cytoplasm, and a few azurophilic granules may be
present. Large lymphocytes have more cytoplasm and a
similar nucleus. Electron microscopy reveals villi that cover
L-Selectin
LFA-1
9–12 µm
Lymphocyte.
VLA-4
Lymphocyte
Lymphocyte.
CD31
Lymphocyte in peripheral blood.
ICAM-3
CD44
most of the cell surface. Lymphocytes are divided into the
two principal groups of B and T lymphocytes that can be
distinguished phenotypically by their cell surface receptors,
BCRs and TCRs respectively. They are distinguished not
by morphology but by the expression of distinctive surface
molecules that have precise roles in immune reaction. In
L