Untitled - D Ank Unlimited

leukocytosis 449 leukotriene
Leukocytoclastic vasculitis.
Arachidonic acid
COOH
leukocytosis
An above-normal increase of peripheral blood leukocytes
as reflected by a total white blood cell count >11,000/mm of
blood. This occurs frequently with acute infection.
leukopenia
A below-normal reduction of the number of white blood
cells in the peripheral blood.
leukophysin (LKP)
An RNA helicase A-related molecule identified in cytotoxic
T cell granules and vesicles. It is a 28-kDa protein of
cytotoxic T lymphocytes and U937 monocytic cells located
in the membranes of high density granules and lighter cytoplasmic
granules or vesicles. Based on the expression of the
C terminal LKP epitope, vesicular structures and granules
detected in cytotoxic T lymphocytes (CTLs) are distinct
from classical granzyme-containing cytolytic granules.
leukotaxis
Chemotaxis of leukocytes.
leukotriene
An arachidonic acid product generated during an anaphylactic
reaction. May include lipid mediators of inflammation
and type 1 hypersensitivity. Synthesized following
degradation and conversion to arachidonic acid of phospholipids
in macrophage, monocytes, neutrophils, and mast
cell membranes. Leukotriene formation follows arachidonic
acid metabolism via the lipoxygenase pathway. In the past,
leukotrienes were referred to as slow-reacting substances of
anaphylaxis (SRS-A). These lipid inflammatory mediators
are produced by the lipoxygenase pathway in various types
COOH
OOH
12-HPETE
OOH
COOH
5-HPETE
O
COOH
Leukotriene A 4
S-Cys-Gly-Glu
OH
Leukotriene C 4
S-Cys-Gly
OH
Leukotriene D 4
S-Cys
Leukotriene E 4
COOH
COOH
COOH
OH
COOH
OH
12-HETE
OH COOH
5-HETE
COOH
OH
Leukotriene B4 Lipoxygenase pathway or arachidonic acid metabolism that participates in mediation of type I hypersensitivity reactions.
L