Untitled - D Ank Unlimited

Kupffer’s cell 436 Kveim reaction (historical)
Henry George Kunkel.
Kupffer’s cell
A liver macrophage that has become fixed as a mononuclear
phagocytic cell in the liver sinusoids. It is an integral part
of the mononuclear phagocyte (reticuloendothelial) system.
Monocytes become attached to the interior surfaces of liver
sinusoids, where they develop into macrophages. They have
CR1 and CR2 receptors, surface Fc receptors, and major
histocompatibility complex (MHC) class II molecules. They
are actively phagocytic and remove foreign substances from
the blood as it flows through the liver. Under certain disease
conditions, they may phagocytize erythrocytes, leading to
the deposition of hemosiderin particles derived from hemoglobulin
breakdown products.
kuru
A slow virus disease of some native tribes of Guinea that
practice cannibalism. Transmission is through skin lesions
of individuals preparing infected brains for consumption.
The virus accumulates in brain cell membranes.
Kveim reaction (historical)
A skin reaction for the diagnosis of sarcoidosis in which
ground lymph node tissue of a known sarcoidosis patient
is suspended in physiological salt solution and inoculated
intracutaneously into a suspected sarcoidosis patient. A
positive reaction, on histopathologic examination of an
injection-site biopsy 1 month to 6 weeks after inoculation,
reveals a nodular epithelioid cell granuloma-like reaction.
A positive Kveim test confirms the diagnosis of sarcoidosis.
The danger of possibly transmitting hepatitis, AIDS, and
other viruses precludes the use of this reaction.