Untitled - D Ank Unlimited

Ku 435 Kunkel, Henry George (1916–1983)
Georges J.F. Köhler.
Hilary Koprowski.
injections than the Pasteur treatment and eliminated the
possibility of allergy to duck embryo antigens.
Ku
An antigen present in a particle comprised of two noncovalently
linked 70- and 80-kDa proteins that bind DNA.
Nuclear factor IV (NF IV) and Ku antigen are the same.
Anti-Ku antibodies recognize conformational epitopes.
Ku antibodies
Antibodies detectable in 15 to 50% of individuals with
Sjögren’s syndrome, systemic lupus erythematosus (SLE),
mixed connective tissue disease, and scleroderma. They are
found in 5 to 15% of myositis patients in the United States.
Ku antigen
A 70- to 80-kDa DNA-binding protein that is the target of
autoantibodies in a few Japanese myositis patients manifesting
the overlap syndrome.
Ku autoantibodies
Autoantibodies against the Ku epitope that reveal a
strong association with systemic autoimmunity in
Ku antibodies.
Japanese patients in contrast to systemic lupus erythematosus
(SLE) and overlap syndromes in Americans.
These antibodies are also present in selected patients
with mixed connective tissue disease, scleroderma,
polymyositis, Graves’ disease, and primary pulmonary
hypertension, making them nondiagnostic for any
specific autoimmune disease. The Ku autoantigen is a
heterodimeric nucleolar protein composed of 70-kDa
and 80- to 86-kDa subunits which, in association with a
350-kDa catalytic subunit, constitute the DNA-binding
component of a DNA-dependent protein kinase involved
in double-stranded DNA repair and V(D)J recombination.
Ku autoantibodies are of unknown pathogenicity
and clinical significance.
Henry George Kunkel.
Kunkel, Henry George (1916–1983)
American physician and immunologist whose work focused
on immunoglobulins; he characterized myeloma proteins as
immunoglobulins and rheumatoid factor as an autoantibody.
He also discovered IgA and contributed to immunoglobulin
structure and genetics. Kunkel received the Lasker Award
and the Gairdner Award. A graduate of Johns Hopkins
Medical School, he served as a professor of medicine at the
Rockefeller Institute for Medical Research.
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