Untitled - D Ank Unlimited

Job’s syndrome 426 Jones–Mote reaction
Bronchus
Job’s syndrome with bronchogenic abscess.
Job’s syndrome
Recurring cold staphylococcal abscesses or infections by
other agents. Eczema, elevated levels of immunoglobulin E
(IgE) in the serum, and phagocytic dysfunction are associated
with glutathione reductase and glucose-6-phosphatase
deficiencies. The syndrome has an autosomal-recessive
mode of inheritance.
johnin
An extract from culture medium in which Mycobacterium
johnei is growing. It can be used in a skin test of cattle for
the diagnosis of Johne’s disease. Its preparation parallels
the extraction of the purified protein derivative (PPD) used
in the tuberculin test.
joining (J) gene segment
A type of gene segment in immunoglobulin and T-cell
receptor genes that is rearranged to render functional variable
region exons.
Jones criteria
Signs and symptoms used in the diagnosis of acute rheumatic
fever.
95
Germline sequence
Vχ21 C C C C C C T G G Jχ1 Junctional diversity.
Jones–Mote hypersensitivity
Delayed (type IV) hypersensitivity involving prominent
basophil infiltration of the skin immediately beneath the
epidermis. It can be induced by the intradermal injection
of a soluble antigen such as ovalbumin incorporated into
Freund’s incomplete adjuvant. Swelling of the skin reaches
a maximum 7 to 10 days following induction and vanishes
when antibody is formed. Histologically, basophils predominate,
but lymphocytes and mononuclear cells are also
present. Jones–Mote hypersensitivity is greatly influenced
by lymphocytes that are sensitive to cyclophosphamide
(suppressor lymphocytes).
Cutaneous basophil hypersensitivity.
Jones–Mote reaction
Delayed-type hypersensitivity to protein antigens associated
with basophil infiltration, which gives the reaction
Rearranged
DNA
C C C C C C
C C C C C G
C C C C G G
C C C T G G
C C C C T G G
Amino acid
residues
Pro-Pro
Pro-Pro
Pro-Arg
Pro-Trp
—