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interleukin-8 receptor, type A (IL8RA, α) 407 interleukin-9 (IL9)
serve as tissue sources. Neutrophils, T lymphocytes,
basophils, eosinophils, keratinocytes, and HUVEC cells
serve as targets. The two types of human IL8 receptors
are types A and B consisting of 351 and 360 amino acids,
respectively. They belong to a family of G protein-coupled
receptors with seven transmembrane domains and have
high sequence homologies at the amino acid level. IL8 is
also called CXCL8.
interleukin-8 receptor, type A (IL8RA, )
The high affinity IL8 receptor, class I IL8R belongs to the
G protein-coupled receptor family, the chemokine receptor
branch of the rhodopsin family. The tissue sources are
human neutrophils. Murine IL8 receptor knockout mice
develop splenomegaly, enlarged cervical lymph nodes,
extramedullary myelopoiesis, and impaired neutrophil
acute migration. IL8RA nRNA is present in neutrophils,
monocytes, basophils and freshly isolated T cells.
interleukin-8 receptor, type B (IL8RB, )
A low affinity IL8 receptor, class II, CXCR2, F3R (rabbit).
IL8RB mRNA is present in neutrophils, monocytes, basophils,
T cells, and primary keratinocytes. It is expressed in
the lesional skin of psoriasis patients. G-CSF upregulates
IL8RB mRNA expression, whereas IL8 and MGSA downregulate
IL8RB surface expression on human neutrophils.
interleukin-9 (IL9; murine growth factor P40; T cell growth
factor III)
A cytokine that facilitates the growth of some T helper cell
clones but not cytolytic T lymphocyte clones. It is encoded
by genes comprised of five exons in a 4-kb segment of DNA
in both mice and humans. The gene encoding IL9 is located
on chromosomes 5 and 13. This hematopoietic growth
factor glycoprotein can be derived from a megakaryoblastic
leukemia. Selected human T lymphocyte lines and
peripheral lymphocytes activated by mitogen express it. IL9
is related to mast cell growth-enhancing activity both structurally
and functionally. In the presence of erythropoietin,
IL9 supports erythroid colony formation. In conjunction
with IL2, IL3, IL4, and erythropoietin, IL9 may enhance
hematopoiesis in vivo. It may facilitate bone marrow-derived
mast cell growth stimulated by IL3 and fetal thymocyte
growth in response to IL2. T h2 cells preferentially
express IL9 following stimulation with concanavalin A (con
A) or by antigen presented on syngeneic antigen-presenting
cells.
interleukin-9 (IL9)
A cytokine synthesized by T cells and specifically by CD4 +
helper cells. It facilitates the growth of some T helper cell
clones but not of clones of cytolytic T lymphocytes. It is
encoded by genes comprised of 5 exons in the 4-kb segment
of DNA in both mice and humans. In the presence of
erythropoietin, IL9 supports erythroid colony formation.
In conjunction with IL2, IL3, IL4, and erythropoietin, IL9
may enhance hematopoiesis in vivo. It may facilitate bone
marrow-derived mast cell growth stimulated by IL3 and
fetal thymocyte growth in response to IL2. Th2 cells preferentially
express IL9 following stimulation with con A or by
antigen presented on syngeneic antigen-presenting cells. It
is a hematopoietic growth factor glycoprotein derived from
a megakaryoblastic leukemia. Selected T lymphocyte lines
and peripheral lymphocytes activated by mitogen express
it. IL9 is related to mast cell growth-enhancing activity
both structurally and functionally. The genes encoding IL9
COOH
Interleukin-9 receptor. Schematic representation of the interleukin-9 (IL-9)
receptor, only one type of which has been found on murine T cell lines.
Investigation of the recombinant murine receptor has demonstrated association
between the IL-2Rγ chain and the IL-9R. Macrophages, some T cell
tumors, and mast cell lines have been shown to express IL-9 receptors.
Cysteine
Cysteine
Cysteine
Cysteine
WSEWS
Homology
with IL-2Rβ
Serine-rich
region
Extracellular
Cytoplasmic
Schematic representation of the Il-9 receptor.
are located on chromosomes 5 and 13. Genes encoding
this cytokine are believed to have a role in asthma. Genetic
I