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interleukin-6 receptor 405 interleukin-7 (IL7)
Pathway of IL-6 induction and signaling.
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α-chain β-chain
(gp130)
Interleukin-6 receptor.
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α-chain
Interleukin-7 receptor.
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γ c -chain
produce it. IL6 also acts as a costimulator of T lymphocytes
and thymocytes. It acts in concert with other cytokines that
promote the growth of early bone marrow hematopoietic
stem cells. It acts with IL1 to costimulate activation of Th
cells. IL6 was formerly termed B cell differentiation factor
(BCDF) and B cell-stimulating factor 2 (BSF-2). It has
been implicated in the pathogenesis of plaques in psoriasis.
With IL1 and TNF-α, IL6 produces a broad spectrum of
responses early in infection.
interleukin-6 receptor
A structure composed of 468 amino acids: a 19-amino
acid signal peptide, a 339-amino acid extracellular portion,
a 28-amino acid transmembrane domain, and an
82-amino acid intracytoplasmic portion. The receptor has
six potential N-linked glycosylation sites and 11 cysteine
residues. The mature receptor has a molecular weight of 80
kDa and O- and N-glycosylation. The IL6 receptor system
is composed of two functional chains, the ligand-binding
80-kDa IL6 receptor and the nonligand-binding gp130.
This receptor is expressed on lymphoid as well as nonlymphoid
cells. IL6 signals via a cell surface type I cytokine
receptor complex comprised of the ligand-binding IL6Rα
chain (CD126) and the signal-transducing component gp130
(CD130). Interaction of IL6 with this receptor leads to activation
of gp 130 and IL6R proteins to produce a complex,
thereby activating the receptor. Such complexes assemble
the intracellular regions of gp 130 to activate a signal
transduction cascade through such transcription factors as
Janus kinases (JAKs) and signal transducers and activators
of transcription (STATs).
interleukin-7 (IL7)
Interleukin-7 facilitates lymphoid stem cell differentiation
into progenitor B cells. It mainly serves as a T lymphocyte
growth factor synthesized by bone marrow stromal cells. It
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