Untitled - D Ank Unlimited

immunoglobulin M (IgM) 374 immunoglobulin M (IgM)
Deletion
Inversion
C 1
5'
5'
J 2
J 1
V1 V2 V3 Vη D1 D2 D3 D4 Dη J1 J2 J3 J4 J5 J6 C µ Cδ Embryonic DNA
Pre-B cell DNA
L 1 V 1 L 2 V 2 L n V n
L 1
C 2
C 1 C 2 J 1 J 2
V 1 D 4
DNA rearrangement,
deletion
J1 J2 J3 J4 J5 J6 Immunoglobulin gene rearrangement (see previous figure for key).
Heavy chain
Light chain
Immunoglobulin heavy chains that are fastened to each other or to light polypeptide
changes by disulfide bonds.
V 1
Sister chromatid exchange:
duplicated sister chromatids
V 1
V 2
V 14
V 14
V1 V 2 J 2 J 3
D 1
C µ
D 2
D n J E C µ
L 2 V 2 L n V n D n J E C µ
Daughter cells
J 2 J 3 V 1 J 2 J 3
V1 V2 V3 J2 J3 Immunoglobulin gene rearrangement (see previous figure for key).
C δ
3'
Photomicrograph of immunoglobulin κ light chain “staining” by
immunoperoxidase.
3'