Untitled - D Ank Unlimited

adoptive immunization 22 adoptive transfer
IL-2
adoptive immunization
The passive transfer of immunity by the injection of
lymphoid cells from a specifically immune individual to a
previously nonimmune recipient host. The recipient is said
to have adoptive immunity.
adoptive immunotherapy
The experimental treatment of terminal cancer patients
who have metastatic tumors unresponsive to other modes
of therapy by the inoculation of lymphokine-activated
killer (LAK) cells or tumor-infiltrating lymphocytes
(TILs) together with interleukin-2 (IL-2). This mode of
therapy has shown some success in approximately one
IL-12
IL-2
NK cell
Tc cell or
CTL precursor
IL-12
NK cell
CTL
differentiation
Cytotoxic
T lymphocyte
(CTL)
Fc receptor
Perforin and
granzymes
Cytotoxic
T lymphocyte
(CTL)
CD8+
MHC class I
receptor
TCR
Epitope
CD8+
Perforin and
granzymes
TNFα
Tumor cell
Tumor cell
Interleukin-2 (IL-2) immunotherapy.
Perforin and
granzymes
Epitope
Fc receptor
Perforin and
granzymes
MHC class I
receptor
IgG antibody
Tumor cell
lysis
Tumor cell
lysis
tenth of treated individuals who have melanoma or renal
cell carcinoma.
adoptive tolerance
The passive transfer of immunologic tolerance with
lymphoid cells from an animal tolerant to that antigen
to a previously nontolerant and irradiated recipient host
animal.
adoptive transfer
A synonym for adoptive immunization; the passive transfer
of lymphocytes from an immunized individual to a nonimmune
subject with immune system cells such as CD4 + T
lymphocytes. Tumor-reactive T cells have been adoptively
transferred for experimental cancer therapy.
Tumor cell
IgG antibody
Tumor cell
TNFα
Interleukin-12 (IL-12) immunotherpy.
Tumor cell
lysis
IgG antibody
Tumor cell
lysis