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idiotype suppression 351 Igα and Igβ
Anti-idiotype antibody
against V region
structure outside
binding site
idiotype suppression
The inhibition of idiotype antibody production by suppressor
T lymphocytes activated by antiidiotype antibodies.
idiotype vaccine
Antibody preparation that mimics antigens at the molecular
level. These vaccines induce immunity specific for the
antigens they mimic. They are not infectious to recipients,
are physiologic, and can be used in place of many antigens,
e.g., the idiotype vaccine related to Plasmodium falciparum
circumsporozote (CS) protein.
idiotypic determinant
Refer to epitope.
idiotypic specificity
Characteristic folding of the antigen-binding site, thereby
exposing various groups that, by their arrangement, confer
antigenic properties to the immunoglobulin V region.
Antibodies against a specific antigen usually carry both a
few predominant idiotypes and other similar, but not identical,
crossreacting idiotypes. The proportion between the
two indicates the degree of heterogeneity of the antibody
response in a given individual.
id reaction
Dermatophytid reaction. A sudden rash linked to, but
anatomically separated from, an inflammatory reaction
of the skin in a sensitized individual with the same types
of lesions elsewhere. The hands and arms are usual sites
of id reactions that are expressed as sterile papulovesicular
pustules. They may be linked with dermatophytosis
such as tinea capitis or tinea pedis. They may also be
associated with stasis dermatitis, contact dermatitis, and
eczema.
IE
Acronym for immunoelectrophoresis.
IEF
Acronym for isoelectric focusing.
IEP
Acronym for immunoelectrophoresis.
Antigen
Idiotype
Idiotype network.
The shape of the antigen
and the shape of the
anti-idiotype are similar
Anti-idiotype antibody
against binding site
i-exons
Leader-like sequences present in the C H region of the IgH
locus, where transcription of germline C H transcripts requisite
for switch recombination begins.
IFE
Acronym for immunofixation electrophoresis.
IFN
Acronym for interferon.
IFN-
Abbreviation for interferon-α.
IFN-
Abbreviation for interferon-β.
IFN-
Abbreviation for interferon-γ.
Ig/Ig complex
A B cell receptor complex accessory heterodimer needed to
transduce intracellular signaling activated by mIg interaction
with antigen. Igα and Igβ cytoplasmic tails contain ITAMs.
Ig domain
Refer to immunoglobulin domain.
IGF-II
Insulin-like growth factor-II (IGF-II). A fetal growth factor
expressed at high levels in many tissues during fetal and
early postnatal development but only in the central nervous
system thereafter.
Ig
Abbreviation for immunoglobulin.
Igα and Ig
Proteins on the B cell surface that are noncovalently
associated with cell surface immunoglobulin M (IgM)
and IgD. They link the B cell antigen receptor complex to
intracellular tyrosine kinases. Anti-Ig binding leads to their
phosphorylation. Igα and Igβ are requisite for expression of
IgM and IgD on B cell surfaces. Disulfide bonds link Igα
and Igβ pairs that are associated noncovalently with the
membrane Ig cytoplasmic tail to form the B cell receptor
complex (BRC). The Igα and Igβ cytoplasmic domains bear
I