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I-309
A chemokine of the β (CC) family. It is secreted by activated
T lymphocytes and is a chemoattractant for monocytes. Its
primary structure reveals two characteristics not present in
other β chemokines: two extra cysteine residues in a single
N-linked glycosylation site located in the middle of the β strand
that constitutes the proposed dimer interface. Tissue sources
include T lymphocytes, human mast cells, HMC-1, and murine
mast cell lines. Target cells include monocytes, macrophages,
neutrophils, basophils, and microglial cells.
I invariant (Ii)
Refer to invariant chain.
I-K
Abbreviation for immunoconglutinin.
I region
In the mouse, the DNA segment of the major histocompatibility
complex (MHC) where the gene that encodes MHC
class II molecules is located. The 250-kb I region consists
of I-A and I-E subregions. The genes designated pseudo
Aβ3, Aβ2, Aβ1, and Aβ are located in the 175-kb I-A subregion.
The genes designated Eβ2 and Eα are located in the
75-kb I-E subregion. Eβ1 is located where the I-A and I-E
subregions join. The S region contains the Eβ3 gene.
Ia antigen (immune-associated antigen)
Product of major histocompatibility complex (MHC) class I
region genes that encodes murine cellular antigens. In
humans, the equivalent antigens are designated HLA-DR
and are encoded by MHC class II genes. B lymphocytes,
monocytes, and activated T lymphocytes express Ia antigens.
iatrogenic
A disease or injury resulting from therapy by a medical
practitioner.
IBD
Abbreviation for inflammatory bowel disease.
ibuprofen
Its chemical name is (+)-2-(p-isobutylphenyl)propionic acid.
An antiinflammatory drug used in the therapy of patients
Class II
A
Mhc mouse β3
loci on
chromosome 17
I
with rheumatoid arthritis, ankylosing spondylitis, and juvenile
rheumatoid arthritis.
iC3B (inactivated C3b)
Also designated C3bi.
iC3b-Neo
Complement component C3 expresses a neoepitope not
present on native C3 or C3 degradation products following
activation or cleavage by C3 convertases of the classical or
alternative pathways. Increased iC3b concentrations have
been found in septic shock, transplant rejection, and in
some patients with systemic lupus erythematosus (SLE).
Localized elevations have been found in atherosclerotic
lesions, suggesting a role for complement in atherosclerosis.
The clinical significance of iC3b determination has not yet
been determined.
iC4b
Synonym for C4bi.
ICA512 (IA-2)
A protein tyrosine phosphatase-like molecule that belongs
to a group of transmembrane molecules. It was discovered
by screening islet expression libraries with human insulindependent
diabetes mellitus sera. IA-2 and phogrin are the
two homologs. The IA-2 antigen is expressed in islets and
in the brain.
ICAM-1 (intercellular adhesion molecule 1)
A γ interferon-induced protein necessary for the migration of
polymorphonuclear neutrophils into areas of inflammation.
ICAM-2
Refer to intercellular adhesion molecule 2.
ICAM-3
Refer to intercellular adhesion molecule 3.
iccosomes (immune-complex-coated antibodies)
Small membrane fragments coated with immune complexes
that fragment off follicular dendritic cell processes in lymphoid
follicles early in a secondary or subsequent antibody
response. Iccosomes budding from follicular dendritic cells
can unite with B cell receptors through the presence of
I Region
I-A Subregion I-E Subregion
A β2
Represent individual loci
Indicate the direction
of transcription
A β1 A α
E β1 E β2 E α
In the mouse, the I region is the DNA segment of the major histocompatibility complex, where the genes that encode MHC class II molecules are located.
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