Untitled - D Ank Unlimited

hyperacute xenograft rejection 345 hyperacute xenograft rejection
Hyperacute rejection of renal allograft.
Capillary thrombosis
Hyperacute rejection of renal allotransplant showing swelling and purplish
discoloration. This is a bivalved transplanted kidney. The allograft
was removed within a few hours following transplantation.
A bivalved transplanted kidney showing hyperacute rejection. There is
extensive pale cortical necrosis. This kidney was removed 5 days after
transplantation.
Microscopic view of hyperacute rejection showing a necrotic glomerulus
infiltrated with numerous polymorphonuclear leukocytes. H&E stained
section 25×.
High-power view of hyperacute rejection showing necrotic glomerulus.
There are large numbers of polymorphonuclear leukocytes present.
Extensive endothelial cell destruction is apparent. H&E stained section 50×.
Microscopic view of hyperacute rejection showing necrosis of the wall of
a small arteriole.
specific for antigens of the donor. Produced by complement
activation induced by preformed antibodies that recognize
allogeneic epitopes on the graft vasculature. These antibodies
react with antigens which may be HLA class I antigens
or ABO blood group antigens of endothelial cells lining
capillaries of the donor organ. The reaction sets in motion
a process that culminates in fibrin plugging of the donor
organ vessels, resulting in ischemia and loss of function and
necessitating removal of the transplanted organ. A type II
hypersensitivity mechanism.
hyperacute xenograft rejection
An antigraft immune response mediated by human
natural antibodies that crossreact with porcine xenograft
H