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HUT 78 343 hybrid resistance
Basement membrane
Hump.
John Hunter.
Humps
Subepithelial
deposits
successful in replacing a premolar tooth some hours after
it had been knocked out. He believed he was successful
in transplanting a human tooth into the comb of a cock, a
specimen still on view at the Hunterian Museum.
HUT 78
The original designation for a cell line derived from a
patient with mycosis fungoides (now termed H-9) that was
susceptible to infection with HIV-1 virus; it greatly aided
HIV-1 culture in vitro.
HV regions
Refer to hypervariable regions.
H-Y
A male-specific transplantation antigen. Females of some but
not all inbred mouse strains can reject skin grafts from males of
the same syngeneic strain. By contrast, male-to-male, femaleto-female,
and female-to-male grafts succeed. This finding
Hybrid antibody.
indicates the presence of a minor histocompatibility antigen
gene on the Y chromosome that is H-Y. It is a weak transplantation
antigen compared to the major mouse histocompatibility
complex (MHC) designated H-2. Several H-Y epitopes
have been identified in mice and one in humans. H-Y peptide
epitopes are derived from several linked genes.
hybrid antibody
An immunoglobulin molecule that may be prepared artificially
but may never occur in nature. Each of two antigenbinding
sites is of a different specificity. If immunoglobulin
G (IgG) whole molecules or F(ab′) 2 fragments prepared
from them are subjected to mild reduction, the central disulfide
bond is converted to sulfhydryl groups. A preparation
of half molecules or F(ab′) fragments is produced. If either
of these is reoxidized, hybrid molecules will constitute
some of the products. These can be purified by passing over
immunoadsorbents containing bound antigen of the appropriate
specificity. Hybrid antibodies are monovalent and do
not induce precipitation. They may be used in labeling cell
surface antigens in which one antigen-binding site of the
molecule is specific for cell surface epitopes and the other
combines with a marker that renders the reaction product
visible.
hybrid cell
A cell produced when two cells fuse and their nuclei fuse
to form a heterokaryon. Although hybrid cell lines can be
established from clones of hybrid cells, they lack stability
and delete chromosomes, but they are nevertheless useful
for gene mapping. Hybrid cell lines can be isolated by using
HAT (hypoxanthine, aminopterin, and thymidine) as a
selective medium.
hybrid hapten
A hydrophobic type of hapten that lies within the folds of
a protein carrier away from the aqueous solvent, creating a
new spatial structure.
hybrid resistance
The resistance of members of an F 1 generation of animals to
growth of a transplantable neoplasm from either one of the
parent strains.
H