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homing cell adhesion molecule (H-CAM) 338 homologous recombination
Ab1 Fc
Ab2α
homing cell adhesion molecule (H-CAM)
Also known as CD44, gp 90 hermes , GP85/Pgp-1, and ECMRIII.
H-CAM is a lymphocyte transmembrane glycoprotein with a
molecular weight of 85 to 95 kDa expressed in macrophages,
granulocytes, fibroclasts, endothelial cells, and epithelial
cells. H-CAM has been found to bind to extracellular matrix
molecules such as collagen and hyaluronic acid. It is also an
important signal transduction protein during lymphocyte
adhesion, as it has been demonstrated that phosphorylation
by kinase C and acylation by acyl-transferases enhance the
interactions of H-CAM with cytoskeletal proteins.
homing receptors
Molecules on cell surfaces that direct traffic of the cells to
precise locations in other tissues or organs. For example,
lymphocytes bear surface receptors that facilitate their
attachment to high endothelial cells of postcapillary venules
in lymph nodes. Adhesion molecules present on lymphocyte
surfaces enable lymphocytes to recirculate and home to
specific tissues. Homing receptors bind to ligands termed
addressins found on endothelial cells in affected vessels.
L-selectin on naïve lymphocytes binds to GlyCAM-1 molecules
on high endothelial venules.
Homobody.
homobody
An idiotypic determinant of an antibody molecule with a
three-dimensional structure that resembles antigen. Also
called internal image of antigen. For example, anti-idiotypic
antibodies of this type of insulin receptor may partially
mimic the action of insulin.
Fc
Ab1 Fc
Hof
Homobody.
Ab2β Fc
Ab1
Fc
homocytotrophic antibody
An antibody that attaches better to animal cells of the same
species in which it is produced than to animal cells of a different
species. The term usually refers to an antibody that
becomes fixed to mast cells of an animal of the same species,
resulting in anaphylaxis with the release of pharmacological
mediators of immediate hypersensitivity. These
include histamines and other vasoactive amines when the
mast cells degranulate.
homodimer
A protein composed of dual peptide chains that are identical.
homogenicity
The composition from like parts, elements, or characteristics.
homograft
Allograft (i.e., an organ or tissue graft) from a donor to a
recipient of the same species.
homograft reaction
An immune reaction generated by a homograft (allograft)
recipient against the graft alloantigens. Also called an
allograft reaction.
homograft rejection
Allograft rejection. An immune response induced by histocompatibility
antigens in the donor graft that are not present
in the recipient. This is principally a cell-mediated type of
immune response.
homokaryon
A cell that is multinucleate as a consequence of the fusion
of two or more genetically identical cells.
homologous
Arising from the same source, for example, an organ
allotransplant from one member to a recipient member of
the same species (e.g., renal allotransplantation in humans).
homologous antigen
An antigen (immunogen) that stimulates the synthesis of an
antibody and reacts specifically with it.
homologous chromosomes
A pair of chromosomes containing the same linear gene
sequences, each derived from one parent.
homologous disease
Refer to allogeneic disease and graft-vs.-host disease (GVHD).
homologous recombination
The exchange of DNA fragments between two DNA
molecules or chromatids of paired chromosomes (during
crossing over) at the site of identical nucleotide sequences.
Employed to introduce a mutated version of a gene into
mass embryonic stem cells to produce a knockout mouse or
a mouse manifesting a knock-in transgene.
Fc
Ab2γ