Untitled - D Ank Unlimited

adhesion receptors 20 adjuvant
ICAM-3
LFA-1
CD62L
CD15s
Blood is drawn from the patient
Corrected T-cells are reinfused
into the patient
ICAM-2
LFA-1
CD11b
CD11a
GlyCAM CD54 CD62P CD31
CD26Z
Fibronectin
Antigen Presenting Cell
ICAM-1
LFA-1
T Cell
Adhesion receptors.
ATTACHMENT
(Rolling)
Collagen
LFA-3
(CD58)
CD2
L-B
Laminin
Extracellular Matrix
Adhesion molecule.
ADHESION
T-cells are collected,
cultured, and activated
with interleukin-2
ADA Gene
Cultured T-Cell
DIAPEDESIS
Retrovirus carrying the ADA gene
infects the cultured T-cells,
transferring the gene into the cell
ADA gene is inserted into the
T-cell genome during cell division
Gene therapy for ADA deficiency.
through high endothelial venules have lymph node homing
receptors.
adhesion receptors
Proteins in cell membranes that facilitate the interaction of
cells with matrix. They play a significant role in adherence
and chemoattraction in cell migration. They are divided
into three groups, the first of which is the immunoglobulin
superfamily that contains the T cell receptor/CD3, CD4,
CD8, MHC class I, MHC class II, sCD2/LFA-2, LFA-3/
CD58, ICAM-1, ICAM-2, and VCAM-2. The second group
of adhesion receptors is made up of the integrin family containing
LFA-1, Mac-1, p150,95, VLA-5, VLA-4/LPAM-1,
LPAM-2, and LPAM-3. The third family consists of selectin
molecules including Mel-14/LAM-1, ELAM-1, and CD62.
adjuvant
Substance that facilitates or enhances the immune response
to an antigen with which it is combined. Various types have
been described, including Freund’s complete and incomplete
adjuvants, aluminum compounds, and muramyl dipeptide.
Some of these act by forming a depot in tissues from which
an antigen is slowly released. In addition, Freund’s adjuvant