Untitled - D Ank Unlimited

HLA-A 332 HLA-A, HLA-B, and HLA-C
HIV
virion
CD4
Provirus
latent infection
gp 120
Host cell
Integration
into host DNA
distributed on essentially all nucleated cells of the body and
MHC class II molecules that are distributed on B lymphocytes,
macrophages, and a few other cell types. These are
encoded by genes at the MHC. The HLA locus in humans is
found on the short arm of chromosome 6. This has now been
well defined. In addition to encoding surface isoantigens,
genes at the HLA locus also encode immune response (IR)
genes. The class I region consists of HLA-A, HLA-B, and
HLA-C loci, and the class II region consists of the D region,
which is subdivided into HLA-DP, HLA-DQ, and HLA-DR
subregions. Class II molecules play an important role in the
induction of an immune response, as antigen-presenting cells
must complex an antigen with class II molecules to present
it in the presence of interleukin-1 (IL1) to CD4 + T lymphocytes.
Class I molecules are important in the presentation of
intracellular antigen to CD8 + T lymphocytes and for effector
DP
β
II
DQ
Nucleocapsid
Controlled growth
HIV dsDNA
HIV mRNA
HIV
genomic RNA
Human immunodeficiency virus (HIV) infection.
HIV reverse
transcriptase
HIV ssRNA
RNA–DNA
hybrid
Lytic infection
functions of target cells. Class III molecules encoded by
genes located between those that encode class I and class II
molecules include C2, BF, C4a, and C4b. Class I and class II
molecules play an important role in organ and tissue transplantation.
The microlymphocytotoxicity assay is used for
HLA-A, -B, -C, -DR, and -DQ typing. The primed lymphocyte
test is used for DP typing. Uppercase letters designate
individual HLA loci, such as HLA-B. Alleles are designated
by numbers, such as in HLA-B*0701.
HLA-A
A class I histocompatibility antigen in humans. It is expressed
on nucleated cells of the body. Tissue typing to identify an
individual’s HLA-A antigens employs lymphocytes.
HLA-A, HLA-B, and HLA-C
The highly polymorphic human major histocompatibility
complex (MHC) class I genes.
DZ DO DX
α β α α β β α β α β β β β α OHB C4B OHA C4A Bf C2 TNF TNF B
DR
III
Chromosome 6
HLA is an abbreviation for human leukocyte antigen. The HLA locus in humans is found on the short arm of chromosome 6. The class I region consists of
HLA-A, HLA-B, and HLA-C loci, and the class II region consists of the D region which is subdivided into HLA-DP, HLA-DQ, and HLA-DR subregions.
I
C
A