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HIV-1 virus structure 330 HIV coreceptors
Anti HIV-1 protease Fab.
HIV-1 capsid protein (P24).
A. Parker Hitchens.
HIV-1 virus structure
Human immunodeficiency virus 1 (HIV-1) is composed of
two identical RNA strands that constitute the viral genome.
These are associated with reverse transcriptase and p17 and
p24, which are core polypeptides. These components are
all enclosed in a phospholipid membrane envelope derived
from the host cell. Proteins gp120 and gp41 encoded by the
virus are anchored to the envelope.
5' Long
terminal
repeat
gag gene
pol gene
vif gene
vpr gene
0 Kbp
vpu gene
env gene
tat gene
rev gene
nef gene 3' Long
terminal
repeat
Human immunodeficiency virus 1 (HIV-1) genes..
RNA
Reverse
transcriptase
HIV-1 virus structure.
gp41
IgG/gp
HIV-2
Human immunodeficiency virus 2 (HIV-2) was previously
named HTLV-IV, LAV-2, and SIV/AGM. This virus was
first discovered in individuals from western Africa who
showed aberrant reactions to HIV-1 and simian immunodeficiency
virus (SIV). It shows greater sequence homology
(70%) with SIV/membrane attack complex (MAC) than with
HIV-1 (40% sequence homology). It has only 50% conservation
for gag and pol; the remaining HIV genes are even less
conserved. It has p24, gp36, and gp140 structural antigens.
Its clinical course resembles that of AIDS produced by
HIV-1, but it is confined principally to western Africa and is
transmitted principally through heterosexual promiscuity.
HIV-2V
Human immunodeficiency virus 2 (HIV-2) that possesses
X-ORF and VPX, both of which are unique to it.
HIV coreceptors
Human immunodeficiency virus 1 (HIV-1) virus strains
use the chemokine receptors CCR-5 or CXCR-4 or both to
enter cells. Expression of these receptors may predetermine
susceptibility of hematopoietic subsets to HIV-1 infection.
120 complex.
p17
p24
9
Phospholipid
bilayer
gp120