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Untitled - D Ank Unlimited

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HAT selection 312 HBx<br />

lymphocytes die because of their very limited proliferative<br />

capacity. The hybrid cell that survives in HAT medium<br />

receives the missing enzymes from the lymphocyte and<br />

proliferative capacity from the myeloma cell.<br />

Sachahiro Hata (right) with P. Ehrlich (left).<br />

HAT selection<br />

Refer to HAT medium.<br />

Hata, Sachahiro<br />

Co-discoverer, with his mentor, Paul Ehrlich, of the first<br />

specific treatment for syphilis. They developed the arsenical<br />

compound numbered 606 and named salvarsan.<br />

Felix Haurowitz.<br />

Haurowitz, Felix (1896–1988)<br />

A noted protein chemist from Prague who later moved<br />

to the United States. He investigated the chemistry of<br />

hemoglobins. In 1930 (with Breinl) he advanced the instruction<br />

theory of antibody formation. (Refer to Chemistry<br />

and Biology of Proteins, 1950; Immunochemistry and<br />

Biosynthesis of Antibodies, 1968.)<br />

Hausen, Harald zur<br />

Nobel Laureate in Physiology or Medicine (2008). German<br />

investigator who discovered that some types of human<br />

papilloma virus (HPV) cause cervical cancer.<br />

HAV<br />

Acronym for hepatitis A virus.<br />

hay fever<br />

Allergic rhinitis, recurrent asthma, rhinitis, and conjunctivitis<br />

in atopic individuals who inhale allergenic (antigenic)<br />

materials such as pollens, animal dander, house dust, etc.<br />

These substances do not induce allergic reactions in nonatopic<br />

(normal) individuals. Hay fever is a type I immediate<br />

hypersensitivity reaction mediated by homocytotrophic IgE<br />

antibodies specific for the allergen for which the individual<br />

is hypersensitive. Hay fever is worse during seasons when<br />

airborne environmental allergens are most concentrated.<br />

HBcAg<br />

Hepatitis B core antigen. This 27-nm core can be detected<br />

in hepatocyte nuclei.<br />

HBeAg<br />

Hepatitis B nucleocapsid constituent of relatively low<br />

molecular weight that signifies an infectious state when it<br />

appears in serum.<br />

HBIG (hepatitis B immunoglobulin)<br />

A preparation of donor-pool-derived antibodies against<br />

hepatitis B virus (HBV). It is heat treated and shown not<br />

to contain human immunodeficiency virus (HIV). HBIG<br />

is given at the time when individuals are exposed to HBV<br />

and 1 month thereafter. Low-titer (1:128) and high-titer<br />

(1:100,000) preparations are available.<br />

HBLV (human B lymphotropic virus)<br />

Herpesvirus 6.<br />

HBs antigen in liver cells.<br />

HBsAg<br />

Hepatitis B virus envelope or surface antigen.<br />

HBV<br />

Acronym for hepatitis B virus.<br />

HBx<br />

A regulatory gene of hepatitis B that codes for the production<br />

of an HBx protein that is a transcriptional transactivator<br />

of viral genes. It modifies expression of the host gene.

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