Untitled - D Ank Unlimited

hapten–carrier conjugate 310 Hashimoto’s disease (Hashimoto’s thyroiditis)
+ NN
Diazoarsanilic acid
(hapten)
Tyrosine-containing
protein (carrier)
Only when complexed to a carrier molecule prior to administration
can a hapten induce an immune response. Haptens
usually bear only one epitope. The conjugation of a hapten
to a carrier macromolecule can enable it to enduce a haptenspecific
B and T cell response. Pneumococcal polysaccharide
is an example of a larger molecule that may act as a
hapten in rabbits but as a complete antigen in humans.
hapten–carrier conjugate
The combination of a small molecule covalently linked to a
large immunogenic carrier molecule.
hapten conjugate response
The response to hapten conjugates requires two populations
of lymphocytes: T and B cells. The cells producing the
antibodies are derived from B cells. T cells act as helpers in
this process. B cell preparations, depleted of T cells, cannot
respond to hapten conjugates. The T cells are responsive to
the carrier portion of the conjugate, although in some cases
they also recognize the hapten. The influence of the carrier on
the ensuing response is called carrier effect. The experimental
design for demonstrating the carrier effect involves adoptive
transfer of hapten-sensitive B cells and of T cells primed with
one or another carrier. The primed cells are those that have
already had an opportunity to encounter the antigen.
hapten inhibition test
An assay for serological characterization or elucidation
of the molecular structure of an epitope by blocking the
antigen-binding site of an antibody specific for the epitope
with a defined hapten.
hapten X
Refer to CD15.
HAR
Refer to hyperacute graft rejection.
harderian gland
A tear-secreting gland in the orbit of the eye in mammals
and birds. Immunoglobulin G (IgG), IgM, and secretory
IgA may originate from this location in birds.
OH
CH 2
Protein NH CH C Protein
O
AsO 3H 2
OH
CH 2
NN
Protein NH CH C Protein
Hapten- carrier conjugate.
O
Diazohapten-conjugated
protein
(hapten + carrier)
Milan Hasek.
AsO 3H 2
Hasek, Milan (1925–1985)
Czechoslovakian scientist whose contributions to immunology
include investigations of immunologic tolerance and
the development of chick embryo parabiosis. Hasek also
made fundamental contributions to transplantation biology.
Hashimoto’s disease (Hashimoto’s thyroiditis)
Autoimmune thyroiditis that usually occurs in women past
the age of 40. Thyroid gland inflammation is characterized