Untitled - D Ank Unlimited

H-2 complex
Murine major histocompatibility complex. Comprised of K,
P, A, E, S, D, Q, T, and M loci that contain multiple genes.
Refer to H-2 histocompatibility system.
H-2 histocompatibility system
The major histocompatibility complex of the mouse. H-2
genes are located on chromosome 17. They encode somatic
cell surface antigens and the host immune response (Ir
genes). Each of these has a length of 600 base pairs. The H-2
complex has four regions, designated K, I, S, and D. K region
genes encode class I histocompatibility molecules designated
K. I region genes encode class II histocompatibility molecules
designated I-A and I-E. S region genes encode class
III molecules designated C2, C4, factor B, and cytochrome
P-450 (21-hydroxylase). D region genes encode class I histocompatibility
molecules designated D and L. Antigens that
represent the H-2 type of a particular inbred strain of mice
are encoded by H-2 alleles. Thus, differences in the antigenic
structures of inbred mice of differing H-2 alleles are critical
in the acceptance or rejection of tissue grafts exchanged. K,
D, and L subregions of H-2 correspond to A, B, and C subregions
of human leukocyte antigen (HLA). The I-A and I-E
regions are equivalent to the human HLA-D region.
H-2 locus
The mouse major histocompatibility region on chromosome 17.
H-2 restriction
Major histocompatibility complex (MHC) restriction
involving the murine H-2 MHC.
H-2D
A murine H-2 major histocompatibility complex (MHC)
locus whose products are class I antigens. The H2D gene
has multiple alleles.
H-2I region
A murine H-2 major histocompatibility complex (MHC)
region where the genes encoding class II molecules are found.
K2 K
I-A
Class I
I-E
Aβ3 Aβ2 Aβ Aα Eβ Eβ2 Eα 21-
OHB
TNF
C4
TNF
21-
OHA
D
H
Slp Bf
D2
D3
H-2K
A murine H-2 major histocompatibility complex (MHC)
locus. Genes at this locus, which has multiple alleles,
encode MHC class I antigens.
H-2L
Murine class I histocompatibility antigen found on spleen
cells that serves as a target epitope in graft rejection.
H65-RTA
An immunosuppressant used clinically in the treatment
of acute graft-vs.-host disease and rheumatoid arthritis.
H65-RTA is an immunoconjugate consisting of anti-CD5
monoclonal antibody coupled to a cytotoxic enzyme. It
leads to inhibition of protein synthesis, cell depletion, and
lymphocyte activation.
H7
A pharmacological agent used to study T cell activation. Its
target is protein kinase C.
H antigens
(1) Epitopes on flagellae of enteric bacteria that are motile
and Gram-negative. The H designation is from the German
Hauch, which means breath, and refers to the production of
films on agar plates that resemble breathing on glass. In the
Kaufmann–White classification scheme for Salmonella, H
antigens serve as the basis for the division of microorganisms
into phase I and phase II, depending on the flagellins they
contain. A single cell synthesizes only one type of flagellin.
Phase variation may result in a switch to production of
the other type which is genetically controlled. (2) An ABO
blood group system antigen also called H substance. (3)
Histocompatibility antigen.
H chain (heavy chain)
A principal constituent of immunoglobulin molecules. Each
immunoglobulin is comprised of at least one 4-polypeptide
chain monomer that consists of two heavy and two light
polypeptide chains. The two heavy chains are identical in
Class II
D4
L
Q1
Q2
Class I
Class III
H-2 histocompatibility system is the major histocompatibility complex (MHC) in the mouse.
C2
Q4
Q5
Q6
Q7
Q8/9
Q10
307
H