Untitled - D Ank Unlimited

gut-associated lymphoid tissue (GALT) 305 GVH disease
polyneuritis in which autoimmunity to peripheral nerve
myelin leads to diminished electrical impulse transmission,
resulting in muscle weakness and paralysis. It is often selflimiting
and is associated with recovery from infection by
selected pathogens. It is characterized by chronic demyelination
of peripheral nerves.
Interfollicular
center
Germinal
center
Follicle epithelium
GALT (gut-associated lymphoid tissue).
Peyer’s patch
lymph nodule
from the terminal
ileum
gut-associated lymphoid tissue (GALT)
Lymphoid tissue situated in the gastrointestinal mucosa
and submucosa. It constitutes the gastrointestinal immune
system. GALT is present in the appendix, tonsils, and
Peyer’s patches subjacent to the mucosa. GALT represents
the counterpart of bronchial-associated lymphoid tissue
(BALT) and consists of radially arranged and closely
packed lymphoid follicles that impinge upon the intestinal
epithelium, forming dome-like structures. In GALT,
specialized epithelial cells overlie the lymphoid follicles,
forming a membrane between the lymphoid cells and the
lumen. These cells are called M cells and are believed to
be gatekeepers for molecules passing across. Other GALT
components include IgA-synthesizing B cells and intraepithelial
lymphocytes such as CD8 + T cells, as well as the
lymphocytes in the lamina propria that include CD4 + T
lymphocytes, B lymphocytes that synthesize IgA, and null
cells. Refer also to MALT.
GVH
Refer to graft-vs.-host reaction (GVHR) and graft-vs.-host
disease (GVHD).
GVH disease
Refer to graft-vs-host disease.
G