Untitled - D Ank Unlimited

acute rejection 17 acute rheumatic fever
Acute rejection of a renal allograft in which the capsular surface shows
several hemorrhagic areas. The kidney is tremendously swollen.
Acute rejection of bivalved kidney. The cut surface bulges, is variably
hemorrhagic, and shows fatty degeneration of the cortex.
acute rejection
A type of graft rejection in which T lymphocytes, macrophages,
as well as antibodies may mediate tissue and
vascular injury that may commence a week following transplantation.
The response to the graft includes the activation
of effector T lymphocytes and the formation of antibodies
that may mediate the process.
acute rheumatic fever
Following a group A hemolytic streptococcal infection of
the throat, inflammation of the heart, joints, and connective
tissue may follow. Arthritis may affect several joints
in a migratory pattern. Carditis, inflammation of the heart,
may be associated with the development of high titer heartreactive
antibodies (HRAs) that have been implicated in
the pathogenesis of rheumatic fever. A patient may develop
HRA, rheumatic fever, or both. HRA development in rheumatic
fever represents molecular mimicry. Selected antistreptococcal
cell wall M protein antibodies are crossreactive
through molecular mimicry with myocardial epitopes of the
human heart. These serve as sites of attachment for IgG and
Microscopic view of the interstitium revealing predominantly cellular
acute rejection. There is an infiltrate of variably sized lymphocytes and an
infiltrate of eosinophils.
Microscopic view of acute rejection showing interstitial edema. Mild lymphocytic
infiltrate. In the glomerulus, there is also evidence of predominantly
vast rejection with a thrombus at the vascular pole.
A higher magnification of the thrombus at the hilus of the glomerulus.
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