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gp41 300 graft
changed the understanding of the role lymphocytes play
in immune reactions. He also investigated lymphocyte
function. He served as director of the MRC Cellular
Immunobiology Unit, Oxford, 1963.
gp41
A human immunodeficiency virus (HIV) glycoprotein that
anchors gp120 in the HIV envelope.
gp120
A surface 120-kDa glycoprotein of human immunodeficiency
virus type 1 (HIV-1) that combines with the CD4
receptor on T lymphocytes and macrophages. The principal
envelope protein of HIV, which binds to host cell receptors
and expresses immunodominant epitopes. Synthetic soluble
CD4 molecules have been used to block gp120 antigens and
spare CD4 + lymphocytes from becoming infected. The env
gene, which mutates frequently, encodes gp120, thereby
interfering with host efforts to manufacture effective or
protective antibodies.
gp160 vaccine
A vaccine that contains a cloned segment of the envelope
protein of HIV-1. It activates both humoral and cellular
immunity against HIV products during early infection with
HIV-1 and diminishes the rate at which CD4 + T lymphocytes
are lost.
GPLA
The guinea pig major histocompatibility complex (MHC).
Two loci encode MHC class I molecules: GPLA-B and
GPLA-S. The GPLA-Ia locus encodes MHC class II
molecules. Complement protein factors B, C2, and C4 are
encoded by other loci. The genes are BF (factor B), C2, C4,
Ia, B, and S.
Pierre Grabar.
Grabar, Pierre (1898–1986)
French-educated immunologist born in Kiev who served as
chef de service at the Institut Pasteur and as director of the
National Center for Scientific Research, Paris. Best known
for his work with Williams in the development of immunoelectrophoresis.
He studied antigen–antibody interactions
and developed the “carrier” theory of antibody function. He
was instrumental in reviving European immunology in the
era after World War II.
St. Cosmas and St. Damian transplanting the leg of a Moor onto the stump of
a young man who lost his leg.
2.
1.
Isograft
(genetically
identical)
3.
Allograft
Types of grafts.
Autograft
Xenograft
graft
The transplantation of a tissue or organ from one site to
another within the same individual or between individuals
of the same or a different species.