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GOR autoantibodies 299 Gowans, James (1924–)
Goodpasture’s syndrome. Stained with anti-glomerular basement membrane
(anti-GBM) antibody.
Goodpasture’s syndrome. Stained with anti-glomerular basement membrane
(anti-GBM) antibody.
Goodpasture’s syndrome. Stained with anti-lung alveolar basement membrane
antibody.
pattern of immunofluorescent staining confirms interaction
of the immunoglobulin G (IgG) antibodies with basement
membrane antigens in the kidney and lung, leading to membrane
injury with pulmonary hemorrhage and acute (rapidly
progressive or crescentic) proliferative glomerulonephritis.
Pulmonary hemorrhage may precede hematuria. In addition
to linear IgG, membranes may reveal linear staining for C3.
GOR autoantibodies
GOR autoantibodies are detected in approximately 80%
of patients with HCV-RNA-positive chronic hepatitis C
infection, in fewer than 10% of chronic HBV or alcohol
misuse cases, and in approximately 2% of normal subjects.
These autoantibodies recognize an epitope of the
sequence GRRGQKAKSNPNRPL, which is common to
a presumed core gene product of HCV and a host nuclear
component. GOR autoantibodies are detected also in most
HCV-antibody-positive patients with LKM-1-autoantibodypositive
autoimmune hepatitis type 2b.
Peter Alfred Gorer.
Gorer, Peter Alfred (1907–1961)
British pathologist. With Snell, he discovered the H-2
murine histocompatibility complex. Most of his work was
in transplantation genetics. He identified antigen II and
described its association with tumor rejection. (Refer to The
Gorer Symposium, 1985.)
James Gowans.
Gowans, James (1924–)
British physician and investigator whose principal contribution
to immunology was the demonstration that lymphocytes
recirculate via the thoracic duct, which radically
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