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Golgi apparatus 298 Goodpasture’s syndrome
Golgi apparatus
A stack of vesicles enclosed by membranes found within a
cell that serves as a site of glycosylation and packaging of
secreted proteins. It is part of the GERL complex.
Golgi autoantibodies.
Golgi autoantibodies
Autoantibodies against Golgi apparatus cisternal and
vesicular membranes are very rare. Golgi apparatus is
a target of heterogenous autoantibodies with specificity
for certain autoantigens that include golgin 95, golgin
160, golgin 97, golgin 180, macrogolgin, and GCp372.
Immunofluorescence using Hep-2 cells is the technique
employed to detect the Golgi autoantibodies, but no diagnostic
significance has yet been correlated with disease
activity.
Golgi complex
Tubular cytoplasmic structures that participate in protein
secretion. The complex consists of flattened membranous
sacs (cisternae) arranged on top of each other. These are
also associated with spherical vesicles. Proteins arriving
from the rough endoplasmic reticulum are processed in the
Golgi complex and sent elsewhere in cells. Proteins handled
in this manner include those that are secreted constitutively
such as immunoglobulins, those of the membrane, those
stored in secretory granules to be released on command,
and lysosomal enzymes.
gonococcal complement fixation test
A complement fixation test that uses as antigen an extract
of Neisseria gonorrhoea. It is of little value in diagnosing
early cases of gonorrhea that appear before the generation
of an antibody response but may be used to identify late
manifestations in untreated individuals.
Good, Robert Alan (1922–2003)
American immunologist and pediatrician who made major
contributions to studies of the ontogeny and phylogeny of
the immune response. Much of his work focused on the
role of the thymus and the bursa of Fabricius in immunity.
(Refer to The Thymus in Immunobiology, 1964; Phylogeny
of Immunity, 1966.)
Goodpasture, Ernest W. (1886–1960)
Professor and chair of pathology at Vanderbilt University
Medical School, for whom Goodpasture’s syndrome is
named. He was a pioneer in virology and had a distinguished
career in basic medical research and as an administrator.
He also served as dean of the Vanderbilt Medical
School.
Robert Alan Good.
Ernest W. Goodpasture.
Goodpasture’s antigen
An antigen found in the noncollagenous part of type IV
collagen. It is present in human glomerular and alveolar
basement membranes, making them targets for injuryinducing,
anti-GBM (glomerular basement membrane) antibodies
in the sera of patients with Goodpasture’s syndrome.
Interestingly, individuals with Alport’s (hereditary) nephritis
do not have the Goodpasture antigen in their basement
membranes. Thus, renal transplants stimulate anti-GBM
antibodies in such patients.
Goodpasture’s syndrome
An autoimmune disease mediated by Type II hypersensitivity
in which autoantibodies target collagen epitopes present
in kidney and lung basement membranes. It is a disease
with pulmonary hemorrhage (coughing up blood) and glomerulonephritis
(blood in the urine) induced by antiglomerular
basement membrane autoantibodies that also interact
with alveolar basement membrane antigens. A linear