Untitled - D Ank Unlimited

genetic polymorphism 292 genotype
Deletion:
Inversion:
C 1
C 1
L 1
L 1
may be introduced into any murine gene by permitting investigation
of this alteration in vivo. Technological advances that
made this possible include using homologous recombination
to introduce defined changes into the murine genome and the
reintroduction of genetically altered embryonic stem cells
into the murine germline to produce mutant mouse strains.
genetic polymorphism
Variation in a population attributable to the existence of two
or more alleles of a gene.
genetic switch hypothesis
A concept that predicts a switch in the gene governing
heavy chain synthesis by plasma cells during immune
response ontogeny.
V 1
V 2
V1 L2 V2 Ln Vn Dn Sister chromatid exchange:
Duplicated sister chromatids Daughter cells
5'
5'
V 1
J 2
C 2
J 1
J 1
C 2
J 2
V 14
V 14
L 2
V2 J2 J3 V1 J2 V1 V2 J2 J3 V1 V2 V2 L n
V n
D 1
Immunoglobulin gene rearrangement.
J 3
D 2
D n
J
genome
All genetic information contained in a cell or in a gamete;
the total genetic material found in the haploid set of
chromosomes.
genomic DNA
DNA found in the chromosomes. Refer to DNA.
genomics
Study of an organism’s complete genome.
genotype
The genetic makeup of an organism. It constitutes the
combined genetic constituents inherited from both parents
and refers to the alleles present at one or more specific loci.
When referring to microinjected transgenes, mice can be
V1 V2 V3 Vη D1 D2 D3 D4 Dη J1 J2 J3 J4 J5 J6 Embryonic DNA
Pre-B cell DNA
DNA Rearrangement,
deletion
V1 D4 J1 J2 J3 J4 J5 J6 Gene rearrangement.
C µ
C δ
3'
J 2
J
E
J 3
E
C µ
C µ
C δ
C µ
3'