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gene amplification 290 gene escape mutant
Antigen and
antibody movement
Appearance
of stained gel
present on leukemic blast cells in most acute myelogenous
leukemia patients. Toxicities include myelosuppression,
including neutropenia, hepatotoxicity, and hypersensitivity
reactions.
gene amplification
One of more duplications of a gene or its chromosomal
region to yield many copies of that gene in the genome.
gene bank
DNA library.
gene cloning
The use of recombinant DNA technology to replicate genes
or their fragments.
gene conversion
Recombination of two homologous genes in which a local
segment of one gene is replaced by a homologous segment
of a second gene. In avian species and lagomorphs, gene
conversion facilitates immunoglobulin receptor diversity
principally through homologous, inactive V gene segments
exchanging short sequences with an active, rearranged
variable-region gene.
Polymerized beads
Well of antigen
Gel diffusion.
Precipitin line
Large proteins
Gel filtration chromatography.
Well of antibody
gene conversion hypothesis
Method by which alternative sequences can be introduced
into major histocompatibility complex (MHC) genes
without reciprocal crossover events. This mechanism may
account for the incredible polymorphism of alleles. The
alternative sequences may include those found in the class
I-like genes and pseudogenes present on chromosome 6.
Hypothetically, gene conversion was an evolutionary event
as well as an ongoing one, giving rise to new mutations,
therefore new alleles, within a population.
gene diversity
Determination of the extent of an immune response to a
particular antigen or immunogen by mixing and matching
of exons from variable, joining, diversity, and constant
region gene segments. S. Tonegawa received a Nobel Prize
for revealing the mechanism of the generation of diversity
in antibody formation.
gene escape mutant
A pathogenic microorganism that avoids host immune
response or drug therapy by causing a mutation in a gene
Small proteins