Untitled - D Ank Unlimited

acute lymphoblastic leukemia (ALL) 14 acute lymphoblastic leukemia (ALL)
HLA-DR
CD3
0 SS 1023
10 3
10 2
10 1
10 0
10 3
10 2
10 1
10 0
10 0
M1 M2
11.6% 3.5%
M3
3.7%
M4
1.3%
J1 J2
76.0% 9.2%
J3 J4
4.1% 10.7%
10 1 10 2 10 3
CD45 ECD
10 0 10 1 10 2 10 3
CD13
CD3 Positive
CD45
Positive
CD13 Negative
10 0 10 1 10 2 10 3
translocation of c-myc protooncogene on chromosome 8
to the immunoglobulin coding gene region on chromosome
14. Lymphoblasts that are unable to differentiate and
mature continue to accumulate in the bone marrow. ALL
patients develop anemia, granulocytopenia, and thrombocytopenia.
L1, L2, and L3 lymphoblast cytologic subtypes
are recognized. ALL is diagnosed by the demonstration
of lymphoblasts in the bone marrow. The total leukocyte
count is normal or decreased in half of the cases with or
without lymphoblasts in the peripheral blood. An elevated
leukocyte count is usually accompanied by lymphoblasts
HLA-DR
CD10
CD5
10 3
10 2
10 1
10 0
10 3
10 2
10 1
10 0
M3 M4
5.0% 79.1%
10 0
J1 J2
76.0% 9.2%
J3 J4
4.1% 10.7%
10 0
M1 M2
0.7% 82.5%
M3
11.9%
10 0
M4
4.9%
101 CD7
CD19 CD2 RD1
10 3
10 2
10 1
10 0
T cell acute lymphoblastic leukemia.
M1 M2
9.5% 6.4%
HLA-DR Negative
CD7 Positive
10 1
CD19
10 1
10 2
CD19 Negative
CD10 Positive
10 2
CD2 Positive
CD5 Positive
10 2
10 3
10 3
10 3
in the peripheral blood. Patients develop a normochromic,
normocytic anemia with thrombocytopenia and neutropenia.
They may develop weakness, malaise, and pallor
secondary to anemia. Half the individuals develop bleeding
secondary to thrombocytopenia, and many develop
bacterial infections secondary to neutropenia. Patients
also experience bone pain. Generalized lymphadenopathy
especially affects the cervical lymph nodes. Frequently,
hepatosplenomegaly and leukemic meningitis are present.
The age at onset and initial total blood leukocyte count
are valuable prognostic features. Ninety percent (90%) of